Macrophages

Blood monocytes that enter damaged tissues from the circulation differentiate into macrophages. These specialised phagocytic cells recognise, engulf and degrade cellular debris and pathogens and can survive several months. They function both in innate and adaptative immunity and are also essential for wound healing processes.

Latest Research and Reviews

  • Reviews |

    Tumour-associated macrophages (TAMs) promote cancer initiation and malignant progression. This Review evaluates current strategies to target TAMs, exploring their toxicity and compensatory mechanisms, and proposes novel strategies in light of new findings regarding macrophage biology and their mechanism of action.

    • Luca Cassetta
    •  & Jeffrey W. Pollard
  • Research | | open

    Communication between osteoblasts and osteoclasts is essential for bone homeostasis, but the mode of interaction is unclear. The authors use intravital two-photon microscopy in mice to show that these cells directly interact, regulating activity of osteoclasts, and that the interaction is modulated by parathyroid hormone administration.

    • Masayuki Furuya
    • , Junichi Kikuta
    • , Sayumi Fujimori
    • , Shigeto Seno
    • , Hiroki Maeda
    • , Mai Shirazaki
    • , Maki Uenaka
    • , Hiroki Mizuno
    • , Yoriko Iwamoto
    • , Akito Morimoto
    • , Kunihiko Hashimoto
    • , Takeshi Ito
    • , Yukihiro Isogai
    • , Masafumi Kashii
    • , Takashi Kaito
    • , Shinsuke Ohba
    • , Ung-il Chung
    • , Alexander C. Lichtler
    • , Kazuya Kikuchi
    • , Hideo Matsuda
    • , Hideki Yoshikawa
    •  & Masaru Ishii
  • Research | | open

    Short-chain fatty acids (SCFA) are a main class of metabolites derived from fermentation of dietary fibre in the intestine. Here, the authors show that dietary administration of SCFA is associated with inhibition of osteoclast differentiation, increased bone mass, and reduced pathological bone loss in mice.

    • Sébastien Lucas
    • , Yasunori Omata
    • , Jörg Hofmann
    • , Martin Böttcher
    • , Aida Iljazovic
    • , Kerstin Sarter
    • , Olivia Albrecht
    • , Oscar Schulz
    • , Brenda Krishnacoumar
    • , Gerhard Krönke
    • , Martin Herrmann
    • , Dimitrios Mougiakakos
    • , Till Strowig
    • , Georg Schett
    •  & Mario M. Zaiss
  • Research | | open

    Osteoclasts are involved in arthritis, and their differentiation depends on RANKL signaling. The author show that the ROS-scavenging protein DJ-1 negatively regulates RANKL signaling and that its ablation increases osteoclast numbers and exacerbates bone damage in mouse models of arthritis.

    • Hyuk Soon Kim
    • , Seung Taek Nam
    • , Se Hwan Mun
    • , Sun-Kyeong Lee
    • , Hyun Woo Kim
    • , Young Hwan Park
    • , Bokyung Kim
    • , Kyung-Jong Won
    • , Hae-Rim Kim
    • , Yeong-Min Park
    • , Hyung Sik Kim
    • , Michael A. Beaven
    • , Young Mi Kim
    •  & Wahn Soo Choi
  • Research | | open

    Exon skipping is a strategy for the treatment of Duchenne muscular dystrophy, but has variable efficacy. Here, the authors show that dystrophin restoration occurs preferentially in areas of myofiber regeneration, where antisense oligonucleotides are stored in macrophages and delivered to myoblasts and newly formed myotubes

    • James S. Novak
    • , Marshall W. Hogarth
    • , Jessica F. Boehler
    • , Marie Nearing
    • , Maria C. Vila
    • , Raul Heredia
    • , Alyson A. Fiorillo
    • , Aiping Zhang
    • , Yetrib Hathout
    • , Eric P. Hoffman
    • , Jyoti K. Jaiswal
    • , Kanneboyina Nagaraju
    • , Sebahattin Cirak
    •  & Terence A. Partridge
  • Research | | open

    Satellite cells are crucial for growth and regeneration of skeletal muscle. Here the authors show that in response to muscle injury, macrophages secrete Adamts1, which induces satellite cell activation by modulating Notch1 signaling.

    • Hongqing Du
    • , Chung-Hsuan Shih
    • , Michael N. Wosczyna
    • , Alisa A. Mueller
    • , Joonseok Cho
    • , Abhishek Aggarwal
    • , Thomas A. Rando
    •  & Brian J. Feldman

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