Macrophages

Blood monocytes that enter damaged tissues from the circulation differentiate into macrophages. These specialised phagocytic cells recognise, engulf and degrade cellular debris and pathogens and can survive several months. They function both in innate and adaptative immunity and are also essential for wound healing processes.

Latest Research and Reviews

  • Reviews |

    In this Review, Greg Lemke explains how macrophages are able to sense and respond to dead and dying cells. The author discusses the physiological implications of such macrophage activity.

    • Greg Lemke
  • Research | | open

    Control of macrophage adhesion and phenotype is important to biomaterial applications. Here, the authors report on the use of bisphosphonate coated gold nanoparticles by magnesium coordination for the controlled adhesion and polarisation of macrophages in vitro and in vivo and controlled cell release.

    • Heemin Kang
    • , Boguang Yang
    • , Kunyu Zhang
    • , Qi Pan
    • , Weihao Yuan
    • , Gang Li
    •  & Liming Bian
  • Research | | open

    Following muscle damage, an inflammatory response is associated to activation of satellite cells, which drive muscle repair. Here, the authors show that upregulation of Zeb1 in macrophages and muscle fibres regulates inflammation, and also show a role for Zeb1 in maintenance of satellite cell quiescence.

    • Laura Siles
    • , Chiara Ninfali
    • , Marlies Cortés
    • , Douglas S. Darling
    •  & Antonio Postigo
  • Reviews |

    Tumour-associated macrophages (TAMs) promote cancer initiation and malignant progression. This Review evaluates current strategies to target TAMs, exploring their toxicity and compensatory mechanisms, and proposes novel strategies in light of new findings regarding macrophage biology and their mechanism of action.

    • Luca Cassetta
    •  & Jeffrey W. Pollard
  • Research | | open

    Communication between osteoblasts and osteoclasts is essential for bone homeostasis, but the mode of interaction is unclear. The authors use intravital two-photon microscopy in mice to show that these cells directly interact, regulating activity of osteoclasts, and that the interaction is modulated by parathyroid hormone administration.

    • Masayuki Furuya
    • , Junichi Kikuta
    • , Sayumi Fujimori
    • , Shigeto Seno
    • , Hiroki Maeda
    • , Mai Shirazaki
    • , Maki Uenaka
    • , Hiroki Mizuno
    • , Yoriko Iwamoto
    • , Akito Morimoto
    • , Kunihiko Hashimoto
    • , Takeshi Ito
    • , Yukihiro Isogai
    • , Masafumi Kashii
    • , Takashi Kaito
    • , Shinsuke Ohba
    • , Ung-il Chung
    • , Alexander C. Lichtler
    • , Kazuya Kikuchi
    • , Hideo Matsuda
    • , Hideki Yoshikawa
    •  & Masaru Ishii
  • Research | | open

    Short-chain fatty acids (SCFA) are a main class of metabolites derived from fermentation of dietary fibre in the intestine. Here, the authors show that dietary administration of SCFA is associated with inhibition of osteoclast differentiation, increased bone mass, and reduced pathological bone loss in mice.

    • Sébastien Lucas
    • , Yasunori Omata
    • , Jörg Hofmann
    • , Martin Böttcher
    • , Aida Iljazovic
    • , Kerstin Sarter
    • , Olivia Albrecht
    • , Oscar Schulz
    • , Brenda Krishnacoumar
    • , Gerhard Krönke
    • , Martin Herrmann
    • , Dimitrios Mougiakakos
    • , Till Strowig
    • , Georg Schett
    •  & Mario M. Zaiss

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