Lysosomes are subcellular organelles that are mainly responsible for degradation of proteins internalized by cells by endocytosis and phagocytosis. Upon uptake, proteins and soluble components from the extracellular space pass through endosomes before fusing and/or maturing to form lysosomes. During the endosome–lysosome transition, the compartmental pH drops, which is conducive to the function of lysosomal acid hydrolases.

Latest Research and Reviews

News and Comment

  • News and Views |

    Rag GTPases play a crucial role in mTORC1 activation by promoting its recruitment to the lysosomal surface in a nutrient-dependent manner. A study now identifies a family of lysosomal G-protein-coupled receptors as modulators of Rag GTPases localization and activation, adding one more component to the fast-growing mTOR regulatory network.

    • Rosa Puertollano
    Nature Cell Biology 21, 538-539
  • News and Views |

    Newly synthesised lysosomal proteins are sorted from other cargo on the secretory pathway for delivery to endolysosomal compartments. A study now shows that the Batten disease protein, CLN8, acts as a recycling receptor to sort soluble lysosomal enzymes for export from the endoplasmic reticulum to the Golgi.

    • J. Paul Luzio
    Nature Cell Biology 20, 1333-1335
  • News and Views |

    Rag GTPases facilitate mTORC1 activation by recruiting it to Rheb at the lysosome when amino acids are abundant. A study now shows that the amino acid-induced change in the GTP/GDP-binding state of the Rag heterodimer paradoxically increases its dynamic release from the Ragulator at the lysosome and may limit mTORC1 activation.

    • Aaron M. Hosios
    •  & Brendan D. Manning
    Nature Cell Biology 20, 996-997