Lymphopoiesis

Definition

Lymphopoiesis is the process in which lymphocytes (B cells, T cells and NK cells) develop from progenitor cells. B cell lymphopoiesis is completed in the bone marrow, whereas T cell lymphopoiesis occurs in the thymus.

Latest Research and Reviews

  • Research |

    The size of immune-cell populations needs to be tightly regulated. Shinohara and colleagues demonstrate that intracellular and secreted osteopontin control the contraction and expansion of myeloid and lymphoid populations differently under infectious and autoimmune conditions.

    • Masashi Kanayama
    • , Shengjie Xu
    • , Keiko Danzaki
    • , Jason R Gibson
    • , Makoto Inoue
    • , Simon G Gregory
    •  & Mari L Shinohara
  • Research |

    Expression of a competent Igh heavy chain initiates a pre-BCR checkpoint during B cell development. Reth and colleagues show that protein arginine methylation by a BTG2-PRMT1 complex is required to inactivate CDK4 and thereby establish pre-B cell arrest.

    • Elmar Dolezal
    • , Simona Infantino
    • , Friedel Drepper
    • , Theresa Börsig
    • , Aparajita Singh
    • , Thomas Wossning
    • , Gina J Fiala
    • , Susana Minguet
    • , Bettina Warscheid
    • , David M Tarlinton
    • , Hassan Jumaa
    • , David Medgyesi
    •  & Michael Reth
    Nature Immunology 18, 911–920
  • Research | | open

    Treg cells suppress peripheral immune responses, but their function in haematopoiesis is unclear. Here the authors show they modulate the bone marrow microenvironment to sustain haematopoietic stem cell-driven generation of mature B cells.

    • Antonio Pierini
    • , Hidekazu Nishikii
    • , Jeanette Baker
    • , Takaharu Kimura
    • , Hye-Sook Kwon
    • , Yuqiong Pan
    • , Yan Chen
    • , Maite Alvarez
    • , William Strober
    • , Andrea Velardi
    • , Judith A. Shizuru
    • , Joy Y. Wu
    • , Shigeru Chiba
    •  & Robert S. Negrin
  • Research |

    Transcription factors compete for superenhancer sites and have antagonist functions. Farrar and colleagues identify regulatory competition between STAT5 and IKAROS or NF-κB in B cells and show that the ratio of STAT5 to IKAROS or to NF-κB can serve as a prognostic marker of disease severity of the leukemia B-ALL.

    • Casey D S Katerndahl
    • , Lynn M Heltemes-Harris
    • , Mark J L Willette
    • , Christine M Henzler
    • , Seth Frietze
    • , Rendong Yang
    • , Hilde Schjerven
    • , Kevin A T Silverstein
    • , Laura B Ramsey
    • , Gregory Hubbard
    • , Andrew D Wells
    • , Roland P Kuiper
    • , Blanca Scheijen
    • , Frank N van Leeuwen
    • , Markus Müschen
    • , Steven M Kornblau
    •  & Michael A Farrar
    Nature Immunology 18, 694–704
  • Research | | open

    ILC2 and ILC3 are generally thought to require IL-7. Here the authors use IL-7 ko mice and provide side-by-side comparison of ILCs from different tissues to show that IL-7 signalling is not required for intestinal ILC maintenance or function and that IL-15 can compensate for absence of IL-7.

    • Michelle L. Robinette
    • , Jennifer K. Bando
    • , Wilbur Song
    • , Tyler K. Ulland
    • , Susan Gilfillan
    •  & Marco Colonna

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