Lymphoid tissues

Lymphoid tissues are organized structures that support immune responses. The bone marrow and thymus are primary lymphoid tissues and the sites of lymphocyte development. The lymph nodes, spleen, tonsils and Peyer’s patches are examples of secondary lymphoid tissue. Chronic inflammation can lead to the development of tertiary lymphoid tissue.

Latest Research and Reviews

  • Reviews |

    Turley and Krishnamurty review new insights into lymph node stromal cells, a heterogeneous cell population that serves distinct functions during development, in maintaining lymphocyte homeostasis, and in coordinating immune responses.

    • Akshay T. Krishnamurty
    •  & Shannon J. Turley
    Nature Immunology 21, 369-380
  • Research
    | Open Access

    Immune cells mostly enter lymph nodes (LN) from blood circulation, but whether afferent lymphatics contributes to LN entry is unclear. Here, the authors show, using a photo-convertible reporter, that T cells in afferent lymphatics frequently enter LN and become arrested in the subcapsular sinus, with chemokines and integrins further guiding their migration in the LN.

    • Rieke Martens
    • , Marc Permanyer
    • , Kathrin Werth
    • , Kai Yu
    • , Asolina Braun
    • , Olga Halle
    • , Stephan Halle
    • , Gwendolyn E. Patzer
    • , Berislav Bošnjak
    • , Friedemann Kiefer
    • , Anika Janssen
    • , Michaela Friedrichsen
    • , Jenny Poetzsch
    • , Karan Kohli
    • , Yvonne Lueder
    • , Rodrigo Gutierrez Jauregui
    • , Nadine Eckert
    • , Tim Worbs
    • , Melanie Galla
    •  & Reinhold Förster
  • Research
    | Open Access

    • Carolina V. Messias
    • , Guilherme Loss-Morais
    • , Joseane Biso de Carvalho
    • , Mariela N. González
    • , Daniela P. Cunha
    • , Zilton Vasconcelos
    • , Luis W. P. Arge
    • , Désio A. Farias-de-Oliveira
    • , Alexandra L. Gerber
    • , Elyzabeth A. Portari
    • , Nilma Ferreira
    • , Lidiane M. S. Raphael
    • , Myrna C. Bonaldo
    • , Ingo Riederer
    • , Maria E. Lopes Moreira
    • , Vinicius Cotta-de-Almeida
    • , Ana T. R. Vasconcelos
    • , Daniella A. Mendes-da-Cruz
    •  & Wilson Savino
  • Research
    | Open Access

    Lymphatic endothelial cells (LECs) can cross-present antigen to naïve CD8+ T cells, but the significance of this interaction was unclear. Here the authors show that LECs directly induce CD8+ T cell differentiation with memory-like phenotypes, migration patterns and transcriptome, which can later be recalled to promote effector immunity and protection from Listeria infection.

    • Efthymia Vokali
    • , Shann S. Yu
    • , Sachiko Hirosue
    • , Marcela Rinçon-Restrepo
    • , Fernanda V. Duraes
    • , Stefanie Scherer
    • , Patricia Corthésy-Henrioud
    • , Witold W. Kilarski
    • , Anna Mondino
    • , Dietmar Zehn
    • , Stéphanie Hugues
    •  & Melody A. Swartz
  • Research
    | Open Access

    Fibroblastic reticular cells (FRC) are important for lymph node (LN) structure and function. Here the authors show that the YAP/TAZ complex downstream of Hippo signalling regulates FRC commitment and maturation, with YAP/TAZ deficiency impairing FRC differentiation, while hyperactivation of YAZ/TAZ inducing myofibroblastic FRCs and LN fibrosis.

    • Sung Yong Choi
    • , Hosung Bae
    • , Sun-Hye Jeong
    • , Intae Park
    • , Hyunsoo Cho
    • , Seon Pyo Hong
    • , Da-Hye Lee
    • , Choong-kun Lee
    • , Jin-Sung Park
    • , Sang Heon Suh
    • , Jeongwoon Choi
    • , Myung Jin Yang
    • , Jeon Yeob Jang
    • , Lucas Onder
    • , Jeong Hwan Moon
    • , Han-Sin Jeong
    • , Ralf H. Adams
    • , Jin-Man Kim
    • , Burkhard Ludewig
    • , Joo-Hye Song
    • , Dae-Sik Lim
    •  & Gou Young Koh

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