Lymphoid tissues

Lymphoid tissues are organized structures that support immune responses. The bone marrow and thymus are primary lymphoid tissues and the sites of lymphocyte development. The lymph nodes, spleen, tonsils and Peyer’s patches are examples of secondary lymphoid tissue. Chronic inflammation can lead to the development of tertiary lymphoid tissue.

Latest Research and Reviews

  • Reviews |

    Nanoscale and microscale materials can be used as drug delivery vehicles to target specific lymph node-resident cell subtypes for immunotherapy. In this Review, the authors discuss the transport mechanisms to and from lymph nodes and how they can be explored for drug delivery.

    • Alex Schudel
    • , David M. Francis
    •  & Susan N. Thomas
  • Research | | open

    The white pulp of spleen is an important immune structure dynamically modulated during development and immune responses. Here the authors define, using multi-color lineage tracing and single-cell transcriptome analysis, the subset distribution and differentiation trajectory of fibroblastic reticular cells to serve structural insights for splenic white pulps.

    • Hung-Wei Cheng
    • , Lucas Onder
    • , Mario Novkovic
    • , Charlotte Soneson
    • , Mechthild Lütge
    • , Natalia Pikor
    • , Elke Scandella
    • , Mark D. Robinson
    • , Jun-ichi Miyazaki
    • , Anne Tersteegen
    • , Ursula Sorg
    • , Klaus Pfeffer
    • , Thomas Rülicke
    • , Thomas Hehlgans
    •  & Burkhard Ludewig
  • Research |

    Fibroblastic reticular cells support lymph-node function and adaptive immunity. McGeachy and colleagues show that the cytokine IL-17 is needed to trigger metabolic changes required for the proliferation and survival of these cells in reactive lymph nodes.

    • Saikat Majumder
    • , Nilesh Amatya
    • , Shankar Revu
    • , Chetan V. Jawale
    • , Dongwen Wu
    • , Natalie Rittenhouse
    • , Ashley Menk
    • , Saran Kupul
    • , Fang Du
    • , Itay Raphael
    • , Amrita Bhattacharjee
    • , Ulrich Siebenlist
    • , Timothy W. Hand
    • , Greg M. Delgoffe
    • , Amanda C. Poholek
    • , Sarah L. Gaffen
    • , Partha S. Biswas
    •  & Mandy J. McGeachy
    Nature Immunology 20, 534-545
  • Reviews |

    Engineering immune cells and organs using materials enables the investigation of immune responses and the development of immunotherapies. In this Review, the authors discuss 2D and 3D approaches to recreate key cell-level, tissue-level and organ-level immune functionalities of primary, secondary and tertiary lymphoid organs.

    • Sungwoong Kim
    • , Shivem B. Shah
    • , Pamela L. Graney
    •  & Ankur Singh
  • Research | | open

    Burkitt lymphoma (BL) is the most common pediatric B-cell lymphoma. Here, within the International Cancer Genome Consortium, the authors performed whole genome and transcriptome sequencing of 39 sporadic BL, describing the landscape of mutations, structural variants, and mutational processes that underpin this disease how alterations on different cellular levels cooperate in deregulating key pathways and complexes.

    • Cristina López
    • , Kortine Kleinheinz
    • , Sietse M. Aukema
    • , Marius Rohde
    • , Stephan H. Bernhart
    • , Daniel Hübschmann
    • , Rabea Wagener
    • , Umut H. Toprak
    • , Francesco Raimondi
    • , Markus Kreuz
    • , Sebastian M. Waszak
    • , Zhiqin Huang
    • , Lina Sieverling
    • , Nagarajan Paramasivam
    • , Julian Seufert
    • , Stephanie Sungalee
    • , Robert B. Russell
    • , Julia Bausinger
    • , Helene Kretzmer
    • , Ole Ammerpohl
    • , Anke K. Bergmann
    • , Hans Binder
    • , Arndt Borkhardt
    • , Benedikt Brors
    • , Alexander Claviez
    • , Gero Doose
    • , Lars Feuerbach
    • , Andrea Haake
    • , Martin-Leo Hansmann
    • , Jessica Hoell
    • , Michael Hummel
    • , Jan O. Korbel
    • , Chris Lawerenz
    • , Dido Lenze
    • , Bernhard Radlwimmer
    • , Julia Richter
    • , Philip Rosenstiel
    • , Andreas Rosenwald
    • , Markus B. Schilhabel
    • , Harald Stein
    • , Stephan Stilgenbauer
    • , Peter F. Stadler
    • , Monika Szczepanowski
    • , Marc A. Weniger
    • , Marc Zapatka
    • , Roland Eils
    • , Peter Lichter
    • , Markus Loeffler
    • , Peter Möller
    • , Lorenz Trümper
    • , Wolfram Klapper
    • , Susanne Wagner
    • , Gesine Richter
    • , Jürgen Eils
    • , Jules Kerssemakers
    • , Christina Jaeger-Schmidt
    • , Ingrid Scholz
    • , Christoph Borst
    • , Friederike Braulke
    • , Martin Dreyling
    • , Sonja Eberth
    • , Hermann Einsele
    • , Norbert Frickhofen
    • , Siegfried Haas
    • , Dennis Karsch
    • , Nicole Klepl
    • , Michael Kneba
    • , Jasmin Lisfeld
    • , Luisa Mantovani-Löffler
    • , German Ott
    • , Christina Stadler
    • , Peter Staib
    • , Thorsten Zenz
    • , Dieter Kube
    • , Ulrike Kostezka
    • , Vera Binder
    • , Ellen Leich
    • , Inga Nagel
    • , Jordan Pischimariov
    • , Stefan Schreiber
    • , Inga Vater
    • , Lydia Hopp
    • , David Langenberger
    • , Maciej Rosolowski
    • , Steve Hoffmann
    • , Ralf Küppers
    • , Birgit Burkhardt
    • , Matthias Schlesner
    •  & Reiner Siebert

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