Lymphocyte activation

Lymphocyte activation occurs when lymphocytes (B cells or T cells) are triggered through antigen-specific receptors on their cell surface. This causes the cells to proliferate and differentiate into specialized effector lymphocytes. For example, activated B cells can give rise to antibody-producing cells and some activated T cells become cytotoxic T cells.

Latest Research and Reviews

  • Research | | open

    The differentiation and function of regulatory T (Treg) cells are critically controlled by T cell receptor (TCR) signaling. Here the authors show that CARD11-BCL10-MALT1 (CBM) complexes are dispensable for effector Treg conversion under inflammatory conditions but are critical for mediating Treg suppressive activity in a MALT1 paracaspase-dependent manner.

    • Marc Rosenbaum
    • , Andreas Gewies
    • , Konstanze Pechloff
    • , Christoph Heuser
    • , Thomas Engleitner
    • , Torben Gehring
    • , Lara Hartjes
    • , Sabrina Krebs
    • , Daniel Krappmann
    • , Mark Kriegsmann
    • , Wilko Weichert
    • , Roland Rad
    • , Christian Kurts
    •  & Jürgen Ruland
  • Research |

    Oliver and colleagues use di-glycine remnant profiling in combination with whole-cell proteomics and transcriptomics to identify ubiquitylated proteins and predict degradative or non-degradative outcomes of ubiquitylation in activated primary mouse CD4+ T cells.

    • Joseph M. Dybas
    • , Claire E. O’Leary
    • , Hua Ding
    • , Lynn A. Spruce
    • , Steven H. Seeholzer
    •  & Paula M. Oliver
    Nature Immunology 20, 747-755
  • Research | | open

    T-cell subsets differ in metabolic requirements for particular tasks. Here the authors characterize metabolic fluxes in naïve human CD4+ cells upon activation, and identify a role of Stat5 in glutaminolysis linked to IL-2 production.

    • Nicholas Jones
    • , Emma E. Vincent
    • , James G. Cronin
    • , Silvia Panetti
    • , Megan Chambers
    • , Sean R. Holm
    • , Sian E. Owens
    • , Nigel J. Francis
    • , David K. Finlay
    •  & Catherine A. Thornton
  • Reviews |

    Engineering immune cells and organs using materials enables the investigation of immune responses and the development of immunotherapies. In this Review, the authors discuss 2D and 3D approaches to recreate key cell-level, tissue-level and organ-level immune functionalities of primary, secondary and tertiary lymphoid organs.

    • Sungwoong Kim
    • , Shivem B. Shah
    • , Pamela L. Graney
    •  & Ankur Singh
  • Research | | open

    • Rebar N. Mohammed
    • , Sophie C. Wehenkel
    • , Elena V. Galkina
    • , Emma-Kate Yates
    • , Graham Preece
    • , Andrew Newman
    • , H. Angharad Watson
    • , Julia Ohme
    • , John S. Bridgeman
    • , Ruban R. P. Durairaj
    • , Owen R. Moon
    • , Kristin Ladell
    • , Kelly L. Miners
    • , Garry Dolton
    • , Linda Troeberg
    • , Masahide Kashiwagi
    • , Gillian Murphy
    • , Hideaki Nagase
    • , David A. Price
    • , R. James Matthews
    • , Vera Knäuper
    •  & Ann Ager
  • Research |

    Mass cytometry identifies a unique phenotype enriched in CD4+ T cells isolated from autoimmune disease patients.

    • Asbjørn Christophersen
    • , Eivind G. Lund
    • , Omri Snir
    • , Elsa Solà
    • , Chakravarthi Kanduri
    • , Shiva Dahal-Koirala
    • , Stephanie Zühlke
    • , Øyvind Molberg
    • , Paul J. Utz
    • , Mina Rohani-Pichavant
    • , Julia F. Simard
    • , Cornelia L. Dekker
    • , Knut E. A. Lundin
    • , Ludvig M. Sollid
    •  & Mark M. Davis
    Nature Medicine 25, 734-737

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