Lymph node

Lymph nodes are small organs that are distributed throughout the body and drain lymph fluid from the tissues. Immune cells reside in lymph nodes and survey the lymph for signs of infection. If a tissue is infected, immune cells in the draining lymph node become activated and proliferate.

Latest Research and Reviews

  • Reviews |

    In this Review, the authors describe technologies for image-guided surgery for managing lymphatic metastases in prostate cancer. Refining these technologies should increase precision in the surgical recognition of positive lymph nodes and reduce the morbidity of pelvic lymph node dissection.

    • Fijs W. B. van Leeuwen
    • , Alexander Winter
    • , Henk G. van Der Poel
    • , Matthias Eiber
    • , Nazareno Suardi
    • , Markus Graefen
    • , Friedhelm Wawroschek
    •  & Tobias Maurer
  • Research | | open

    Induction of tolerance in the gut relies on immunomodulatory functions of mesenteric lymph nodes (mLN). Here the authors show that mLN stromal cells receive early microbiota imprinting in the neonatal phase to exhibit long-term, location-specific transcriptional programs for the induction of regulatory T cells and peripheral tolerance.

    • Joern Pezoldt
    • , Maria Pasztoi
    • , Mangge Zou
    • , Carolin Wiechers
    • , Michael Beckstette
    • , Guilhem R. Thierry
    • , Ehsan Vafadarnejad
    • , Stefan Floess
    • , Panagiota Arampatzi
    • , Manuela Buettner
    • , Janina Schweer
    • , Diana Fleissner
    • , Marius Vital
    • , Dietmar H. Pieper
    • , Marijana Basic
    • , Petra Dersch
    • , Till Strowig
    • , Mathias Hornef
    • , André Bleich
    • , Ulrike Bode
    • , Oliver Pabst
    • , Marc Bajénoff
    • , Antoine-Emmanuel Saliba
    •  & Jochen Huehn
  • Research | | open

    Memory B cells need to be reactivated to produce high affinity antibody responses on subsequent antigen encounters. Here the authors show that memory B cells localise to lymph node subcapsular proliferative foci (SPF), which have distinct properties from the germinal centre, for rapid expansion and the induction of B memory responses.

    • Imogen Moran
    • , Akira Nguyen
    • , Weng Hua Khoo
    • , Danyal Butt
    • , Katherine Bourne
    • , Clara Young
    • , Jana R. Hermes
    • , Maté Biro
    • , Gary Gracie
    • , Cindy S. Ma
    • , C. Mee Ling Munier
    • , Fabio Luciani
    • , John Zaunders
    • , Andrew Parker
    • , Anthony D. Kelleher
    • , Stuart G. Tangye
    • , Peter I. Croucher
    • , Robert Brink
    • , Mark N. Read
    •  & Tri Giang Phan
  • Reviews |

    Radical cystectomy plus concurrent pelvic lymph node dissection (PLND) provides oncological benefit and useful prognostic information. However, a lack of consensus exists regarding the optimal PLND template. Here, the authors describe and discuss the use of different PLND templates.

    • Marlon Perera
    • , Shannon McGrath
    • , Shomik Sengupta
    • , Jack Crozier
    • , Damien Bolton
    •  & Nathan Lawrentschuk

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