Long-term memory

Long-term memory is information encoded in the brain on the time-scale of years. It consists of explicit (declarative) memories that are consciously reportable and depend heavily on the medial temporal lobe and hippocampus and implicit (procedural) memories that are unconscious and depend on the basal ganglia and cerebellum.

Latest Research and Reviews

News and Comment

  • News and Views |

    Using light-activated ion channels to stimulate sensory and motivational pathways, Vetere and colleagues constructed fully artificial memories in mice. Mice preferred or avoided an odor they had never smelled before, depending on the pattern of stimulation.

    • Mark G. Baxter
    •  & Nicholas A. Upright
    Nature Neuroscience 22, 845-846
  • News and Views |

    Experience unfolds continuously in time, but we remember discrete sequences of events. In this issue of Nature Neuroscience, Montchal et al. describe brain activity patterns that predict how well people remember precisely when recent events occurred. Converging evidence suggests that homologous neural machinery structures temporal representations in rats and people.

    • Matthew L. Shapiro
    Nature Neuroscience 22, 151-153
  • Research Highlights |

    Study shows that population activity in the rat lateral entorhinal cortex can encode the passage of time, which may contribute to temporal aspects of episodic memory.

    • Katherine Whalley
  • Research Highlights |

    A new study in mice shows that memory engram cells associated with long-term memories form in the prefrontal cortex early during learning in a contextual fear conditioning paradigm and reveals details of the circuitry involved in long-term memory consolidation.

    • Darran Yates