Long non-coding RNAs

Definition

Long non-coding RNAs (lncRNA) are a type of non-coding RNAs (ncRNAs) that exceed 200 nucleotides in length. lncRNAs are a relatively abundant component of the mammalian transcriptome and have been implicated in several cellular functions, including the regulation of gene transcription through the recruitment of chromatin-modifying enzymes.

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Latest Research and Reviews

  • Research |

    Concomitant overexpression of microRNAs miR-100 and miR-125b-1 within the host long non-coding RNA MIR100HG induces cetuximab resistance in cancer in the absence of previously associated genetic alterations. miR-100 and miR-125b target negative regulators of Wnt/β-catenin signaling and sustain drug resistance through feedback inhibition of GATA6 expression and this resistance can be overcome by pharmacological inhibition of Wnt activity. These findings, together with those by Tan et al. in the previous issue, highlight the emerging functional role of non-coding RNAs in modulating the response to anti-cancer therapies.

    • Yuanyuan Lu
    • , Xiaodi Zhao
    • , Qi Liu
    • , Cunxi Li
    • , Ramona Graves-Deal
    • , Zheng Cao
    • , Bhuminder Singh
    • , Jeffrey L Franklin
    • , Jing Wang
    • , Huaying Hu
    • , Tianying Wei
    • , Mingli Yang
    • , Timothy J Yeatman
    • , Ethan Lee
    • , Kenyi Saito-Diaz
    • , Scott Hinger
    • , James G Patton
    • , Christine H Chung
    • , Stephan Emmrich
    • , Jan-Henning Klusmann
    • , Daiming Fan
    •  & Robert J Coffey
  • Reviews |

    Long non-coding RNAs (lncRNAs) are key regulators of gene expression. In this Review, the definition and function of lncRNAs, their importance in immune cell responses and the potential roles of these molecules in rheumatic diseases are discussed.

    • Yuanjia Tang
    • , Tian Zhou
    • , Xiang Yu
    • , Zhixin Xue
    •  & Nan Shen
  • Research | | open

    FoxO are commonly down-regulated transcription factors and tumor suppressors in renal cell cancer (RCC). Here, the authors show that upon energy stress FoxOs induce the expression of the long non-coding RNA FILNC1, which inhibits survival of RCC by downregulating c-Myc and c-Myc-dependent metabolic rewiring.

    • Zhen-Dong Xiao
    • , Leng Han
    • , Hyemin Lee
    • , Li Zhuang
    • , Yilei Zhang
    • , Joelle Baddour
    • , Deepak Nagrath
    • , Christopher G. Wood
    • , Jian Gu
    • , Xifeng Wu
    • , Han Liang
    •  & Boyi Gan
  • Research | | open

    Stable intronic sequence RNAs (sisRNAs) are by-products of splicing from introns with roles in embryonic development in Drosophila. Here, the authors show that the RNA binding protein DIP1 regulates sisRNAs in Drosophila, which is necessary for germline stem cell homeostasis.

    • Jing Ting Wong
    • , Farzanah Akhbar
    • , Amanda Yunn Ee Ng
    • , Mandy Li-Ian Tay
    • , Gladys Jing En Loi
    •  & Jun Wei Pek

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