Ligand-gated ion channels
Ligand-gated ion channels are ion channels that are opened or closed (gated) by ligands, generally small molecules such as the second messenger cAMP and neurotransmitters. Ligand-gated ion channels lead to depolarization or hyperpolarization of the membrane. When located at synapses, ligand-gated ion channels convert the neurotransmitter signal from the pre-synaptic neuron into post-synaptic electrical signals.
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News and Comment
Research Highlights |Nature Reviews Neuroscience 11, 663
Comments and Opinion |Nature Methods 8, 39–42