Leukopoiesis

Leukopoiesis is the process through which leukocytes are generated from haematopoietic stem cells in the bone marrow. The two major forms of leukopoiesis are myelopoiesis and lymphopoiesis. Myelopoiesis generates cells of the innate immune system, whereas lymphopoiesis gives rise to the cells of the adaptive immune system.

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Latest Research and Reviews

  • Research |

    Liu et al. show that the adaptive branch of unfolded protein response signalling, IRE1α–XBP1, protects haematopoietic stem cells and N-Ras pre-leukaemic stem cells from endoplasmic reticulum stress-induced apoptosis and supports their self-renewal.

    • Lu Liu
    • , Meiling Zhao
    • , Xi Jin
    • , Gina Ney
    • , Kevin B Yang
    • , Fanglue Peng
    • , Jin Cao
    • , Takao Iwawaki
    • , Juan Del Valle
    • , Xi Chen
    •  & Qing Li
  • Research |

    Analysis of blood from a healthy human show that haematopoietic stem cells increase rapidly in numbers through early life, reaching a stable plateau in adulthood, and contribute to myeloid and B lymphocyte populations throughout life.

    • Henry Lee-Six
    • , Nina Friesgaard Øbro
    • , Mairi S. Shepherd
    • , Sebastian Grossmann
    • , Kevin Dawson
    • , Miriam Belmonte
    • , Robert J. Osborne
    • , Brian J. P. Huntly
    • , Inigo Martincorena
    • , Elizabeth Anderson
    • , Laura O’Neill
    • , Michael R. Stratton
    • , Elisa Laurenti
    • , Anthony R. Green
    • , David G. Kent
    •  & Peter J. Campbell
    Nature 561, 473-478
  • Research | | open

    IKZF1 is a transcription factor known to regulate mammalian B-cell development. Here the authors show that IKZF1 is required for human pDC development and regulation of DC cytokine production in patients with IKZF1 haploinsufficiency, findings which are recapitulated in lenalidomide-induced IKZF1 deficiency.

    • Urszula Cytlak
    • , Anastasia Resteu
    • , Delfien Bogaert
    • , Hye Sun Kuehn
    • , Thomas Altmann
    • , Andrew Gennery
    • , Graham Jackson
    • , Attila Kumanovics
    • , Karl V. Voelkerding
    • , Seraina Prader
    • , Melissa Dullaers
    • , Janine Reichenbach
    • , Harry Hill
    • , Filomeen Haerynck
    • , Sergio D. Rosenzweig
    • , Matthew Collin
    •  & Venetia Bigley
  • Research | | open

    Tissue-resident macrophages are derived from yolk sac progenitors but how and when these progenitors enter is unclear. Here the authors use fate mapping and intravital microscopy to track the movement of resident macrophage precursors from the yolk sac to fetal tissues during development.

    • C. Stremmel
    • , R. Schuchert
    • , F. Wagner
    • , R. Thaler
    • , T. Weinberger
    • , R. Pick
    • , E. Mass
    • , H. C. Ishikawa-Ankerhold
    • , A. Margraf
    • , S. Hutter
    • , R. Vagnozzi
    • , S. Klapproth
    • , J. Frampton
    • , S. Yona
    • , C. Scheiermann
    • , J. D. Molkentin
    • , U. Jeschke
    • , M. Moser
    • , M. Sperandio
    • , S. Massberg
    • , F. Geissmann
    •  & C. Schulz
  • Research |

    Liu and colleagues show that specification of the dendritic-cell lineage occurs in parallel with specification of the myeloid and lymphoid lineages in or around the hematopoietic-stem-cell stage, starting as a lineage bias defined by transcriptional programs that correlate with the combinatorial dose of IRF8 and PU.1.

    • Jaeyop Lee
    • , Yu Jerry Zhou
    • , Wenji Ma
    • , Wanwei Zhang
    • , Arafat Aljoufi
    • , Thomas Luh
    • , Kimberly Lucero
    • , Deguang Liang
    • , Matthew Thomsen
    • , Govind Bhagat
    • , Yufeng Shen
    •  & Kang Liu
    Nature Immunology 18, 877-888
  • Reviews |

    Recent advances in imaging techniques and genetic tools have rapidly increased our understanding of the niches that maintain adult haematopoietic stem cells, including the constituent cell types and the factors that directly or indirectly regulate these niches.

    • Genevieve M. Crane
    • , Elise Jeffery
    •  & Sean J. Morrison

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