Leukaemia inhibitory factor

Leukaemia inhibitory factor (LIF) is a cytokine of the interleukin-6 family, which is both pro-inflammatory and anti-inflammatory. LIF, acting through its receptor LIFR-α, induces terminal differentiation, and therefore cessation of growth, of myeloid leukaemia cells. LIF also acts on other target cells and tissues, including bone, neurons, heart and embryos, to promote growth and differentiation.

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