Leukaemia inhibitory factor

Definition

Leukaemia inhibitory factor (LIF) is a cytokine of the interleukin-6 family, which is both pro-inflammatory and anti-inflammatory. LIF, acting through its receptor LIFR-α, induces terminal differentiation, and therefore cessation of growth, of myeloid leukaemia cells. LIF also acts on other target cells and tissues, including bone, neurons, heart and embryos, to promote growth and differentiation.

Latest Research and Reviews

  • Research |

    JAK2 phosphorylates H3-Y41 residues to exclude the heterochromatin factor HP1α from chromatin. JAK2 is found to be required for maintenance of mouse embryonic stem cells through its action on the Nanog promoter. A mutant form of JAK2 associated with a myeloproliferative disorder allows embryonic stem cells to self renew in absence of cytokines.

    • Dean S. Griffiths
    • , Juan Li
    • , Mark A. Dawson
    • , Matthew W. B. Trotter
    • , Yi-Han Cheng
    • , Aileen M. Smith
    • , William Mansfield
    • , Pentao Liu
    • , Tony Kouzarides
    • , Jennifer Nichols
    • , Andrew J. Bannister
    • , Anthony R. Green
    •  & Berthold Göttgens