Lamination

Definition

Lamination is the biological process by which cells are arranged in layers within a tissue during development. Laminated structures in the nervous system include the cerebral cortex, retina and hippocampus. During nervous system development, the molecular mechanisms governing cell specification, migration and axon guidance contribute to the process of lamination.

Latest Research and Reviews

  • Research | | open

    Neuronal migration is vital for neuronal circuit morphogenesis and is thought to rely on microtubule-actomyosin crosstalk. Here, the authors use super-resolution imaging and the drebrin microtubule-actin crosslinking protein to show that microtubule-actomyosin coupling controls the direction of centrosome and somal motility.

    • Niraj Trivedi
    • , Daniel R. Stabley
    • , Blake Cain
    • , Danielle Howell
    • , Christophe Laumonnerie
    • , Joseph S. Ramahi
    • , Jamshid Temirov
    • , Ryan A. Kerekes
    • , Phillip R. Gordon-Weeks
    •  & David J. Solecki
  • Research |

    A high-resolution gene expression atlas of prenatal and postnatal brain development of rhesus monkey charts global transcriptional dynamics in relation to brain maturation, while comparative analysis reveals human-specific gene trajectories; candidate risk genes associated with human neurodevelopmental disorders tend to be co-expressed in disease-specific patterns in the developing monkey neocortex.

    • Trygve E. Bakken
    • , Jeremy A. Miller
    • , Song-Lin Ding
    • , Susan M. Sunkin
    • , Kimberly A. Smith
    • , Lydia Ng
    • , Aaron Szafer
    • , Rachel A. Dalley
    • , Joshua J. Royall
    • , Tracy Lemon
    • , Sheila Shapouri
    • , Kaylynn Aiona
    • , James Arnold
    • , Jeffrey L. Bennett
    • , Darren Bertagnolli
    • , Kristopher Bickley
    • , Andrew Boe
    • , Krissy Brouner
    • , Stephanie Butler
    • , Emi Byrnes
    • , Shiella Caldejon
    • , Anita Carey
    • , Shelby Cate
    • , Mike Chapin
    • , Jefferey Chen
    • , Nick Dee
    • , Tsega Desta
    • , Tim A. Dolbeare
    • , Nadia Dotson
    • , Amanda Ebbert
    • , Erich Fulfs
    • , Garrett Gee
    • , Terri L. Gilbert
    • , Jeff Goldy
    • , Lindsey Gourley
    • , Ben Gregor
    • , Guangyu Gu
    • , Jon Hall
    • , Zeb Haradon
    • , David R. Haynor
    • , Nika Hejazinia
    • , Anna Hoerder-Suabedissen
    • , Robert Howard
    • , Jay Jochim
    • , Marty Kinnunen
    • , Ali Kriedberg
    • , Chihchau L. Kuan
    • , Christopher Lau
    • , Chang-Kyu Lee
    • , Felix Lee
    • , Lon Luong
    • , Naveed Mastan
    • , Ryan May
    • , Jose Melchor
    • , Nerick Mosqueda
    • , Erika Mott
    • , Kiet Ngo
    • , Julie Nyhus
    • , Aaron Oldre
    • , Eric Olson
    • , Jody Parente
    • , Patrick D. Parker
    • , Sheana Parry
    • , Julie Pendergraft
    • , Lydia Potekhina
    • , Melissa Reding
    • , Zackery L. Riley
    • , Tyson Roberts
    • , Brandon Rogers
    • , Kate Roll
    • , David Rosen
    • , David Sandman
    • , Melaine Sarreal
    • , Nadiya Shapovalova
    • , Shu Shi
    • , Nathan Sjoquist
    • , Andy J. Sodt
    • , Robbie Townsend
    • , Lissette Velasquez
    • , Udi Wagley
    • , Wayne B. Wakeman
    • , Cassandra White
    • , Crissa Bennett
    • , Jennifer Wu
    • , Rob Young
    • , Brian L. Youngstrom
    • , Paul Wohnoutka
    • , Richard A. Gibbs
    • , Jeffrey Rogers
    • , John G. Hohmann
    • , Michael J. Hawrylycz
    • , Robert F. Hevner
    • , Zoltán Molnár
    • , John W. Phillips
    • , Chinh Dang
    • , Allan R. Jones
    • , David G. Amaral
    • , Amy Bernard
    •  & Ed S. Lein
    Nature 535, 367–375
  • Research |

    A spatially resolved transcriptional atlas of the mid-gestational developing human brain has been created using laser-capture microdissection and microarray technology, providing a comprehensive reference resource which also enables new hypotheses about the nature of human brain evolution and the origins of neurodevelopmental disorders.

    • Jeremy A. Miller
    • , Song-Lin Ding
    • , Susan M. Sunkin
    • , Kimberly A. Smith
    • , Lydia Ng
    • , Aaron Szafer
    • , Amanda Ebbert
    • , Zackery L. Riley
    • , Joshua J. Royall
    • , Kaylynn Aiona
    • , James M. Arnold
    • , Crissa Bennet
    • , Darren Bertagnolli
    • , Krissy Brouner
    • , Stephanie Butler
    • , Shiella Caldejon
    • , Anita Carey
    • , Christine Cuhaciyan
    • , Rachel A. Dalley
    • , Nick Dee
    • , Tim A. Dolbeare
    • , Benjamin A. C. Facer
    • , David Feng
    • , Tim P. Fliss
    • , Garrett Gee
    • , Jeff Goldy
    • , Lindsey Gourley
    • , Benjamin W. Gregor
    • , Guangyu Gu
    • , Robert E. Howard
    • , Jayson M. Jochim
    • , Chihchau L. Kuan
    • , Christopher Lau
    • , Chang-Kyu Lee
    • , Felix Lee
    • , Tracy A. Lemon
    • , Phil Lesnar
    • , Bergen McMurray
    • , Naveed Mastan
    • , Nerick Mosqueda
    • , Theresa Naluai-Cecchini
    • , Nhan-Kiet Ngo
    • , Julie Nyhus
    • , Aaron Oldre
    • , Eric Olson
    • , Jody Parente
    • , Patrick D. Parker
    • , Sheana E. Parry
    • , Allison Stevens
    • , Mihovil Pletikos
    • , Melissa Reding
    • , Kate Roll
    • , David Sandman
    • , Melaine Sarreal
    • , Sheila Shapouri
    • , Nadiya V. Shapovalova
    • , Elaine H. Shen
    • , Nathan Sjoquist
    • , Clifford R. Slaughterbeck
    • , Michael Smith
    • , Andy J. Sodt
    • , Derric Williams
    • , Lilla Zöllei
    • , Bruce Fischl
    • , Mark B. Gerstein
    • , Daniel H. Geschwind
    • , Ian A. Glass
    • , Michael J. Hawrylycz
    • , Robert F. Hevner
    • , Hao Huang
    • , Allan R. Jones
    • , James A. Knowles
    • , Pat Levitt
    • , John W. Phillips
    • , Nenad Šestan
    • , Paul Wohnoutka
    • , Chinh Dang
    • , Amy Bernard
    • , John G. Hohmann
    •  & Ed S. Lein
    Nature 508, 199–206