Kinesins are a large superfamily of cytoskeletal motor protein that hydrolyse ATP to move along microtubules and perform diverse functions in intracellular trafficking and cell division.

Latest Research and Reviews

News and Comment

  • News and Views |

    The combination of topological constraints and deformability in an active system of microtubules and molecular motors leads to rich dynamic behaviour.

    • Julia M. Yeomans
    Nature Materials 13, 1004-1005
  • News and Views |

    Mitosis depends upon the action of the mitotic spindle, a subcellular machine that uses microtubules (MTs) and motors to assemble itself and to coordinate chromosome segregation. Recent work illuminates how the motor-driven poleward sliding of MTs — nucleated at centrosomes, chromosomes and on pre-existing MTs — contributes to spindle assembly and length control.

    • Haifeng Wang
    • , Ingrid Brust-Mascher
    •  & Jonathan M. Scholey
    Nature Cell Biology 16, 737-739
  • News and Views |

    The kinesin-4 motor protein Kif7 regulates Hedgehog signalling at cilia in mammals by controlling the activity of Gli transcription factors. Kif7 is now found to inhibit microtubule growth to restrict and coordinate the length of axonemal microtubules at the ciliary tip. Such Kif7-mediated organization of the ciliary tip compartment regulates Gli activity and is proposed to be required for correct Hedgehog signalling.

    • Lotte B. Pedersen
    •  & Anna Akhmanova
    Nature Cell Biology 16, 623-625
  • News and Views |

    Genetically encoded and post-translationally generated variations of tubulin C-terminal tails give rise to extensive heterogeneity of the microtubule cytoskeleton. The generation of different tubulin variants in yeast now demonstrates how single amino-acid differences or post-translational modifications can modulate the behaviour of selected molecular motors.

    • Annemarie Wehenkel
    •  & Carsten Janke
    Nature Cell Biology 16, 303-305
  • News and Views |

    During mitosis, kinetochores attach to microtubule plus ends, thus allowing dynamic microtubules to properly segregate chromosomes. How this type of 'end-on' attachment between microtubule plus ends and kinetochores is formed and maintained is unclear. CENP-E, a kinesin-7 family member, is now shown to have a role in associating kinetochores with dynamic microtubule plus ends.

    • Melissa K. Gardner
    Nature Cell Biology 15, 1030-1032