Kinesin

Definition

Kinesins are a large superfamily of cytoskeletal motor protein that hydrolyse ATP to move along microtubules and perform diverse functions in intracellular trafficking and cell division.

Latest Research and Reviews

News and Comment

  • News and Views |

    The kinesin-4 motor protein Kif7 regulates Hedgehog signalling at cilia in mammals by controlling the activity of Gli transcription factors. Kif7 is now found to inhibit microtubule growth to restrict and coordinate the length of axonemal microtubules at the ciliary tip. Such Kif7-mediated organization of the ciliary tip compartment regulates Gli activity and is proposed to be required for correct Hedgehog signalling.

    • Lotte B. Pedersen
    •  & Anna Akhmanova
    Nature Cell Biology 16, 623–625
  • News and Views |

    The combination of topological constraints and deformability in an active system of microtubules and molecular motors leads to rich dynamic behaviour.

    • Julia M. Yeomans
    Nature Materials 13, 1004–1005
  • News and Views |

    Mitosis depends upon the action of the mitotic spindle, a subcellular machine that uses microtubules (MTs) and motors to assemble itself and to coordinate chromosome segregation. Recent work illuminates how the motor-driven poleward sliding of MTs — nucleated at centrosomes, chromosomes and on pre-existing MTs — contributes to spindle assembly and length control.

    • Haifeng Wang
    • , Ingrid Brust-Mascher
    •  & Jonathan M. Scholey
    Nature Cell Biology 16, 737–739
  • News and Views |

    Multiple activities cooperate to determine the architecture of the mitotic spindle. Kip3 is a kinesin-8 motor protein in budding yeast that acts as a microtubule depolymerase. Now Kip3 is shown to also crosslink and slide antiparallel microtubules, providing additional insights into how kinesin-8 motors control spindle integrity.

    • Johanna Roostalu
    •  & Thomas Surrey
    Nature Cell Biology 15, 889–891