Kidney diseases

Kidney diseases are hereditary and nonhereditary disorders that affect the kidney. Diabetes mellitus and high blood pressure are important risk factors for kidney disease.

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News and Comment

  • News and Views |

    The PIVOTAL trial shows that proactive intravenous (i.v.) iron administration reduces cardiovascular events and deaths, transfusions and erythropoiesis-stimulating agent doses and does not increase infections in patients on haemodialysis. These findings upend the warnings of guidelines and experts about the dangers of i.v. iron and prove that maintaining low iron stores is harmful.

    • Daniel W. Coyne
  • News and Views |

    A reduction in proteinuria and albuminuria has long been proposed as a surrogate biomarker for clinically validated end points for interventional trials in patients with kidney disease. Taken together, the findings of two recent landmark meta-analyses present a formidable argument favouring such surrogacy but some uncertainty remains.

    • Richard J. Glassock
  • News and Views |

    The analyses in the 2017 Global Burden of Disease Study demonstrate the growing burden of chronic kidney disease (CKD), mainly driven by population ageing; absolute levels for every CKD metric considered rose significantly, whereas age-standardized rates were fairly stable. The prevalence of key metabolic CKD risk factors, particularly obesity, also show a worrying increase.

    • Simon D. S. Fraser
    •  & Paul J. Roderick
  • Comments and Opinion |

    Diagnosis of urinary tract infection (UTI) includes anatomical distinctions because the severity of infection and treatment decisions depend on the infected organ; however, bacterial prostatitis is usually absent from discussions regarding UTI. By considering bacterial prostatitis a UTI, we can increase understanding of the pathogenesis and immune response in the prostate to develop improved therapeutics.

    • Federico Lupo
    •  & Molly A. Ingersoll
  • News and Views |

    New findings demonstrate that endothelial nitric oxide synthase regulates major metabolic pathways in the kidney proximal tubule, which confers protection against oxidative stress during acute kidney injury (AKI). These findings give new insights into AKI pathophysiology and nitric oxide biology, and identify new targets for the treatment of AKI.

    • Pierre-Yves Martin
    •  & Sophie de Seigneux