Isoenzymes articles within Nature Communications

Featured

• Article
  26 May 2023 | Open Access

  The AE4 transporter mediates kidney acid-base sensing

  Maintaining systemic acid-base balance is a central task of the kidneys, but it is still undetermined how acid-base alterations are perceived by the kidney. Here, the authors show that the solute transporter AE4 in β-intercalated cells is an essential part of the renal acid-base sensing mechanism

  • H. Vitzthum
  • , M. Koch
  •  & H. Ehmke

• Article
  11 January 2022 | Open Access

  Transglutaminase 3 crosslinks the secreted gel-forming mucus component Mucin-2 and stabilizes the colonic mucus layer

  The colonic mucus layer is an organized system providing a physical barrier against pathogens and simultaneously harbouring the commensal flora. Here the authors report that transglutaminase 3 activity contributes to homeostasis of the colonic mucus layer and the lack of this enzymatic activity leads to increased susceptibility against DSS-induced colitis in mice.

  • Jack D. A. Sharpen
  • , Brendan Dolan
  •  & Christian V. Recktenwald

• Article
  28 October 2020 | Open Access

  Ketohexokinase-A acts as a nuclear protein kinase that mediates fructose-induced metastasis in breast cancer

  Apart from the enzymatic role of ketohexokinase isoform A (KHK-A) in fructose metabolism the alternative physiological functions of the enzyme are unclear. Here, the authors show that KHK-A mediates fructose-induced metastasis in breast cancer through a nuclear role in repressing the transcriptional activity of the cell-adhesion molecule CDH1.

  • Jiyoung Kim
  • , Jengmin Kang
  •  & Jong-Wan Park

• Article
  13 September 2017 | Open Access

  Engineered factor Xa variants retain procoagulant activity independent of direct factor Xa inhibitors

  A major drawback in the clinical use of the oral anticoagulants that directly inhibit factor Xa in order to prevent blood clot formation is the potential for life threatening bleeding events. Here the authors describe factor Xa variants that are refractory to inhibition by these anticoagulants and could serve as rescue agents in treated patients.

  • Daniël Verhoef
  • , Koen M. Visscher
  •  & Mettine H. A. Bos

• Article
  03 April 2017 | Open Access

  Macrocycle peptides delineate locked-open inhibition mechanism for microorganism phosphoglycerate mutases

  River blindness, a disease affecting millions throughout the tropics, is caused by parasitic worms. Here, Yuet al. report the discovery and structural characterization of potent macrocyclic peptide inhibitors of iPGM, a nematode-specific phosphoglycerate mutase, as potential leads for novel antimicrobial agents.

  • Hao Yu
  • , Patricia Dranchak
  •  & James Inglese