Iron

Definition

Iron (Fe, atomic number 26) is a redox-active transition metal element found in living systems as Fe2+ or Fe3+ ions. It is rarely found free in biology, but is bound to proteins such as ferritin or haem, to form metalloproteins such as haemoglobin, which is responsible for the transport of oxygen in the blood.

Latest Research and Reviews

  • Research | | open

    Hepcidin controls systemic iron levels by inhibiting intestinal iron absorption and iron recycling. Here, Pasricha et al. demonstrate that the hepcidin-chromatin locus displays HDAC3-mediated reversible epigenetic modifications during both erythropoiesis and iron deficiency.

    • Sant-Rayn Pasricha
    • , Pei Jin Lim
    • , Tiago L. Duarte
    • , Carla Casu
    • , Dorenda Oosterhuis
    • , Katarzyna Mleczko-Sanecka
    • , Maria Suciu
    • , Ana Rita Da Silva
    • , Kinda Al-Hourani
    • , João Arezes
    • , Kirsty McHugh
    • , Sarah Gooding
    • , Joe N. Frost
    • , Katherine Wray
    • , Ana Santos
    • , Graça Porto
    • , Emmanouela Repapi
    • , Nicki Gray
    • , Simon J. Draper
    • , Neil Ashley
    • , Elizabeth Soilleux
    • , Peter Olinga
    • , Martina U. Muckenthaler
    • , Jim R. Hughes
    • , Stefano Rivella
    • , Thomas A. Milne
    • , Andrew E. Armitage
    •  & Hal Drakesmith
  • Research | | open

    The biosynthesis of iron-sulfur clusters in anaerobic organisms has not been extensively investigated. Here, the authors identify and characterize a multi-subunit protein that stores iron and sulfur in thioferrate for the assembly of the clusters in Pyrococcus furiosus.

    • Brian J. Vaccaro
    • , Sonya M. Clarkson
    • , James F. Holden
    • , Dong-Woo Lee
    • , Chang-Hao Wu
    • , Farris L. Poole II
    • , Julien J. H. Cotelesage
    • , Mark J. Hackett
    • , Sahel Mohebbi
    • , Jingchuan Sun
    • , Huilin Li
    • , Michael K. Johnson
    • , Graham N. George
    •  & Michael W. W. Adams
  • Research | | open

    The iron-regulated F-box protein FBXL5 regulates iron homeostasis by mediating the degradation of iron regulatory protein 2 (IRP2). Here the authors show that FBXL5 and its regulation of IRP2 are required for HSC self-renewal and reconstitution capability.

    • Yoshiharu Muto
    • , Masaaki Nishiyama
    • , Akihiro Nita
    • , Toshiro Moroishi
    •  & Keiichi I. Nakayama
  • Research |

    Cancer stem cells are typically refractory to conventional treatments. Now, an unprecedented mechanism has been discovered by which salinomycin and derivatives can sequester iron in lysosomes leading to cytoplasmic iron depletion and the subsequent production of reactive oxygen species that are lethal to the cell. This discovery of the importance of iron in cancer stem cell maintenance provides an opportunity for developing new therapeutics.

    • Trang Thi Mai
    • , Ahmed Hamaï
    • , Antje Hienzsch
    • , Tatiana Cañeque
    • , Sebastian Müller
    • , Julien Wicinski
    • , Olivier Cabaud
    • , Christine Leroy
    • , Amandine David
    • , Verónica Acevedo
    • , Akihide Ryo
    • , Christophe Ginestier
    • , Daniel Birnbaum
    • , Emmanuelle Charafe-Jauffret
    • , Patrice Codogno
    • , Maryam Mehrpour
    •  & Raphaël Rodriguez
    Nature Chemistry 9, 1025–1033

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