Iron

Definition

Iron (Fe, atomic number 26) is a redox-active transition metal element found in living systems as Fe2+ or Fe3+ ions. It is rarely found free in biology, but is bound to proteins such as ferritin or haem, to form metalloproteins such as haemoglobin, which is responsible for the transport of oxygen in the blood.

Latest Research and Reviews

  • Research | | open

    The biosynthesis of iron-sulfur clusters in anaerobic organisms has not been extensively investigated. Here, the authors identify and characterize a multi-subunit protein that stores iron and sulfur in thioferrate for the assembly of the clusters in Pyrococcus furiosus.

    • Brian J. Vaccaro
    • , Sonya M. Clarkson
    • , James F. Holden
    • , Dong-Woo Lee
    • , Chang-Hao Wu
    • , Farris L. Poole II
    • , Julien J. H. Cotelesage
    • , Mark J. Hackett
    • , Sahel Mohebbi
    • , Jingchuan Sun
    • , Huilin Li
    • , Michael K. Johnson
    • , Graham N. George
    •  & Michael W. W. Adams
  • Research | | open

    The iron-regulated F-box protein FBXL5 regulates iron homeostasis by mediating the degradation of iron regulatory protein 2 (IRP2). Here the authors show that FBXL5 and its regulation of IRP2 are required for HSC self-renewal and reconstitution capability.

    • Yoshiharu Muto
    • , Masaaki Nishiyama
    • , Akihiro Nita
    • , Toshiro Moroishi
    •  & Keiichi I. Nakayama
  • Research |

    Cancer stem cells are typically refractory to conventional treatments. Now, an unprecedented mechanism has been discovered by which salinomycin and derivatives can sequester iron in lysosomes leading to cytoplasmic iron depletion and the subsequent production of reactive oxygen species that are lethal to the cell. This discovery of the importance of iron in cancer stem cell maintenance provides an opportunity for developing new therapeutics.

    • Trang Thi Mai
    • , Ahmed Hamaï
    • , Antje Hienzsch
    • , Tatiana Cañeque
    • , Sebastian Müller
    • , Julien Wicinski
    • , Olivier Cabaud
    • , Christine Leroy
    • , Amandine David
    • , Verónica Acevedo
    • , Akihide Ryo
    • , Christophe Ginestier
    • , Daniel Birnbaum
    • , Emmanuelle Charafe-Jauffret
    • , Patrice Codogno
    • , Maryam Mehrpour
    •  & Raphaël Rodriguez
  • Research | | open

    The mitochondrial proteins ISCA1 and ISCA2 form a complex that is involved in the biogenesis of Fe–S clusters. Here the authors report that ISCA1 and ISCA2 interact differently with proteins of the Fe–S machinery and that under certain conditions, ISCA2 seems dispensable for Fe–S biogenesis.

    • Lena Kristina Beilschmidt
    • , Sandrine Ollagnier de Choudens
    • , Marjorie Fournier
    • , Ioannis Sanakis
    • , Marc-André Hograindleur
    • , Martin Clémancey
    • , Geneviève Blondin
    • , Stéphane Schmucker
    • , Aurélie Eisenmann
    • , Amélie Weiss
    • , Pascale Koebel
    • , Nadia Messaddeq
    • , Hélène Puccio
    •  & Alain Martelli
  • Reviews |

    Dysregulation of iron homeostasis occurs in haematological disorders and in other diseases such as cancer and neurodegeneration. Crielaard and colleagues discuss the progress made in interfering with iron metabolism as a therapeutic strategy, as well as in using iron metabolism to direct drugs to target tissues.

    • Bart J. Crielaard
    • , Twan Lammers
    •  & Stefano Rivella
  • Research | | open

    Cellular uptake of transition metal ions is mediated by members of the SLC11/NRAMP family. Here the authors determine the structural and functional properties of EcoDMT, a bacterial SLC11 transporter, gathering molecular insight into its transport mechanism and proton coupling process.

    • Ines A. Ehrnstorfer
    • , Cristina Manatschal
    • , Fabian M. Arnold
    • , Juerg Laederach
    •  & Raimund Dutzler

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