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Intrinsic excitability is the electrical excitability of a particular neuron. It is determined by the number and distribution of ion channels and receptors that contribute the electrical properties and depolarization potential of the neuron.
Optogenetics is widely used to study the consequences of neuronal activity with high spatiotemporal precision. In this Review, Kim et al. discuss the integration of this approach with other technological and methodological advances to gain insights into neuronal function that were previously inaccessible.
Immature dentate gyrus neurons are highly excitable and are thought to be more responsive to afferent activity than mature neurons. Here, the authors find stimulation of the entorhinal cortex paradoxically generates spiking in mature rather than immature neurons due to low synaptic connectivity of immature cells.