Intrinsic excitability articles from across Nature Portfolio

CDKL5 deficiency disorder is one of the most common genetic forms of epilepsy. Here the authors show that a model of CDKL5 deficiency disorder involves a channelopathy of CACNA1E gain-of-function, molecularly linking two distinct single-gene developmental and epileptic encephalopathies.

Electrophysiological recordings in murine hippocampal slices show that action potential waveforms mature faster in the bouton than in the soma of adult-born granule neurons

Precise and reliable gene delivery remains technically challenging. Here, the authors show that rationally designed frameshifting splicing can be used to express genes only in targeted cell types, with the potential to enhance the specificity AAV gene delivery.

Most neurons in the nematode C. elegans communicate in an analog manner. Here, the authors demonstrate that enteric motor neurons can fire all-or-none action potentials, and that this digital communication is important for defecation.

Hyperexcitability of a population of arousal-promoting neurons in the hypothalamus drives sleep instability in aged mice.

Peter Lakatos passed away on Sunday, 30 May 2021. He was 49 years old. Peter was a Research Scientist at the Nathan S. Kline Institute for Psychiatric Research in New York State and a Research Assistant Professor in the Department of Psychiatry at NYU Grossman School of Medicine. With Peter’s sudden death, neuroscience has lost a gentle giant.