Intestinal stem cells

Intestinal stem cells are multipotent adult stem cells, which in mammals reside in the base of the crypts of the adult intestine. Intestinal stem cells continuously self-renew by dividing and differentiate into the specialised cells of the intestinal epithelium, which renews throughout life.

Latest Research and Reviews

  • Research | | open

    Whether the Wnt enhanceosome’ components BCL9/9l can affect intestinal homeostasis and tumorigenesis is still unclear. Using conditional Bcl9/9l KO mice, the authors of this study show that the BCL9/9l complex is required for intestinal stem cells to drive tissue regeneration and that loss of BCL9/9l suppresses Wnt-driven transformation.

    • David M. Gay
    • , Rachel A. Ridgway
    • , Miryam Müeller
    • , Michael C. Hodder
    • , Ann Hedley
    • , William Clark
    • , Joshua D. Leach
    • , Rene Jackstadt
    • , Colin Nixon
    • , David J. Huels
    • , Andrew D. Campbell
    • , Thomas G. Bird
    •  & Owen J. Sansom
  • Research |

    Sporadic inactivation of the interleukin-22 receptor in the intestinal epithelium of the mouse shows that IL-22 is required for effective activation of the DNA damage response following DNA damage.

    • Konrad Gronke
    • , Pedro P. Hernández
    • , Jakob Zimmermann
    • , Christoph S. N. Klose
    • , Michael Kofoed-Branzk
    • , Fabian Guendel
    • , Mario Witkowski
    • , Caroline Tizian
    • , Lukas Amann
    • , Fabian Schumacher
    • , Hansruedi Glatt
    • , Antigoni Triantafyllopoulou
    •  & Andreas Diefenbach
    Nature 566, 249-253
  • Research | | open

    Enhanced Wnt receptor activity is a major cause of cancer development. Here the authors identify camelid single-domain antibody fragments (VHHs) that bind to the Wnt receptor LRP5/6 ectodomain, determine the crystal structures and show that these VHHs selectively inhibit Wnt3- mediated cellular responses and block the growth of mutant Wnt-hypersensitive intestinal tumor organoids.

    • Nicola Fenderico
    • , Revina C. van Scherpenzeel
    • , Michael Goldflam
    • , Davide Proverbio
    • , Ingrid Jordens
    • , Tomica Kralj
    • , Sarah Stryeck
    • , Tarek Z. Bass
    • , Guy Hermans
    • , Christopher Ullman
    • , Teodor Aastrup
    • , Piet Gros
    •  & Madelon M. Maurice
  • Reviews |

    The intestinal epithelium undergoes constant replenishment, fuelled by continuously dividing stem cells residing in crypts. In this Review, Gehart and Clevers discuss the signals, cell types and mechanisms that control intestinal stem cell homeostasis and explore how imbalance in key signalling pathways can cause disease.

    • Helmuth Gehart
    •  & Hans Clevers
  • Research | | open

    The mechanisms regulating intestinal stem cell elimination remain unclear. Here, the authors identify that the pro-apoptotic protein ARTS (a Septin4 isoform) interacts with XIAP in the intestinal stem cell niche to  regulate stem cell survival during intestinal homeostasis and regeneration.

    • Elle Koren
    • , Yahav Yosefzon
    • , Roi Ankawa
    • , Despina Soteriou
    • , Avi Jacob
    • , Alexander Nevelsky
    • , Rahamim Ben-Yosef
    • , Gil Bar-Sela
    •  & Yaron Fuchs

News and Comment