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Intermediate filaments are a type of cytoskeletal filaments characterised by their intermediate diameter compared to actin filaments and microtubules. Different types of intermediate filaments are composed by a variety of proteins, including keratins, lamins and vimentin, and may be involved in cell adhesion and maintenance of cellular and nuclear shape.
Cytokinesis in budding yeast is accompanied by a major rearrangement of septins into a double ring. Here, authors show that the F-BAR protein Hof1 contributes to septin remodeling upon its phosphorylation and relocalisation from septins to the division site.
Hair is the main skin appendage of mammals. Here, the authors show that claws of clawed frogs and hair contain homologous keratins and depend on the same transcription factor, Hoxc13, suggesting a common evolutionary origin of these skin appendages.
Using low-input lipidomics in mouse and human embryos, Zhang, Shui, Li and colleagues find that lipid unsaturation increases with development towards the blastocyst stage. They further show that lipid desaturases contribute to successful embryo implantation.
The neurofilament cytoskeleton is critical for axon function and can be dysregulated in disease. Here, the authors show that intracellular glycosylation regulates a key neurofilament protein.
M. Bishr Omary reminds us of the three articles that first uncovered a causative link between mutations in intermediate filaments (specifically, keratin 14) and human diseases.
