Integrin signalling

Definition

Integrin signalling refers to the signal transduction pathways in which integrins at the cell surface respond to mechanical or biochemical stimuli in the extracellular matrix and transmit this information intracellularly to elicit appropriate responses. Integrin signalling is involved in processes including cell migration, proliferation and regulation of cellular shape.

Latest Research and Reviews

  • Research | | open

    The mechanisms underlying tissue fibrosis are unclear. The authors show that mesenchymal cells expressing PDGFRβ mediate fibrosis in skeletal muscle and heart via a mechanism involving αv integrin, and that inhibitors of αv integrins attenuate fibrotic responses in mice.

    • I. R. Murray
    • , Z. N. Gonzalez
    • , J. Baily
    • , R. Dobie
    • , R. J. Wallace
    • , A. C. Mackinnon
    • , J. R. Smith
    • , S. N. Greenhalgh
    • , A. I. Thompson
    • , K. P. Conroy
    • , D. W. Griggs
    • , P. G. Ruminski
    • , G. A. Gray
    • , M. Singh
    • , M. A. Campbell
    • , T. J. Kendall
    • , J. Dai
    • , Y. Li
    • , J. P. Iredale
    • , H. Simpson
    • , J. Huard
    • , B. Péault
    •  & N. C. Henderson
  • Reviews |

    The transcription factors YAP and TAZ have recently emerged as being conserved transducers of mechanical signals into cells and mediators of processes such as proliferation, migration and cell fate decision. The roles of YAP-mediated and TAZ-mediated mechanotransduction have now been documented in many physiological and pathological contexts, providing novel insights into cellular mechano-responses and their consequences.

    • Tito Panciera
    • , Luca Azzolin
    • , Michelangelo Cordenonsi
    •  & Stefano Piccolo
  • Research | | open

    The role of force in activating integrin cell adhesion receptors is not known. Here the authors develop fluorescent tension sensors for αL and β2 integrins and show that in migrating T cells force is transduced across the β2 integrin, and that this correlates with an active conformational state.

    • Pontus Nordenfelt
    • , Hunter L. Elliott
    •  & Timothy A. Springer
  • Reviews |

    Members of the integrin family of receptors, which are involved in cell–cell adhesion, have been successfully targeted for cardiovascular disease, multiple sclerosis and inflammatory bowel disease. Ley and colleagues review the biological basis for the development of the next generation of integrin-targeted drugs, highlighting lessons learned from successes and failures.

    • Klaus Ley
    • , Jesus Rivera-Nieves
    • , William J. Sandborn
    •  & Sanford Shattil
  • Research |

    Ivaska and colleagues report that endocytosed integrins are able to signal from endosomes in an FAK-dependent manner. They further show that endosomal integrin signalling can promote anoikis resistance and lung colonization in cancer cells.

    • Jonna Alanko
    • , Anja Mai
    • , Guillaume Jacquemet
    • , Kristine Schauer
    • , Riina Kaukonen
    • , Markku Saari
    • , Bruno Goud
    •  & Johanna Ivaska
    Nature Cell Biology 17, 1412–1421

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