Innate lymphoid cells

Innate lymphoid cells (ILCs) are immune cells that belong to the lymphoid lineage but do not express antigen-specific receptors. These cells have important functions in innate immune responses to infectious microorganisms and in the regulation of homeostasis and inflammation.

Latest Research and Reviews

  • Research |

    Group 3 innate lymphoid cells are recruited to the lung and involved in the immune response to infection with tuberculosis in humans and mice, as a reduction in group 3 innate lymphoid cells in the lung impaired early immune control of Mycobacterium tuberculosis in mice.

    • Amanda Ardain
    • , Racquel Domingo-Gonzalez
    • , Shibali Das
    • , Samuel W. Kazer
    • , Nicole C. Howard
    • , Alveera Singh
    • , Mushtaq Ahmed
    • , Shepherd Nhamoyebonde
    • , Javier Rangel-Moreno
    • , Paul Ogongo
    • , Lan Lu
    • , Duran Ramsuran
    • , Maria de la Luz Garcia-Hernandez
    • , Tyler K. Ulland
    • , Matthew Darby
    • , Eugene Park
    • , Farina Karim
    • , Laura Melocchi
    • , Rajhmun Madansein
    • , Kaylesh Jay Dullabh
    • , Micah Dunlap
    • , Nancy Marin-Agudelo
    • , Takashi Ebihara
    • , Thumbi Ndung’u
    • , Deepak Kaushal
    • , Alexander S. Pym
    • , Jay K. Kolls
    • , Adrie Steyn
    • , Joaquín Zúñiga
    • , William Horsnell
    • , Wayne M. Yokoyama
    • , Alex K. Shalek
    • , Henrik N. Kløverpris
    • , Marco Colonna
    • , Alasdair Leslie
    •  & Shabaana A. Khader
    Nature, 1-5
  • Reviews |

    Tuft cells captured the attention of immunologists with recent discoveries linking them to type 2 immunity in the small intestine. As described here, these rare secretory epithelial cells act as chemosensory sentinels that detect and relay responses through immune and neuronal cells.

    • Christoph Schneider
    • , Claire E. O’Leary
    •  & Richard M. Locksley
  • Research | | open

    Innate lymphoid cells (ILCs) play critical immunological roles including immune surveillance at mucosal sites. Here the authors show that during nasal inflammation pathogen-induced cytokine production guides the differentiation of ILCs.

    • Korneliusz Golebski
    • , Xavier R. Ros
    • , Maho Nagasawa
    • , Sophie van Tol
    • , Balthasar A. Heesters
    • , Hajar Aglmous
    • , Chantal M. A. Kradolfer
    • , Medya M. Shikhagaie
    • , Sven Seys
    • , P. W. Hellings
    • , Cornelis M. van Drunen
    • , Wytske J. Fokkens
    • , Hergen Spits
    •  & Suzanne M. Bal
  • Research |

    A microbiota- and IL-1β-dependent axis of IL-2 production by group-3 innate lymphoid cells is shown in a mouse model to be necessary to maintain immunological homeostasis and regulatory T cells in the small intestine.

    • Lei Zhou
    • , Coco Chu
    • , Fei Teng
    • , Nicholas J. Bessman
    • , Jeremy Goc
    • , Endi K. Santosa
    • , Gregory G. Putzel
    • , Hiroki Kabata
    • , Judith R. Kelsen
    • , Robert N. Baldassano
    • , Manish A. Shah
    • , Robbyn E. Sockolow
    • , Eric Vivier
    • , Gérard Eberl
    • , Kendall A. Smith
    •  & Gregory F. Sonnenberg
    Nature 568, 405-409

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