Inflammatory diseases

Inflammatory diseases include a vast array of disorders and conditions that are characterized by inflammation. Examples include allergy, asthma, autoimmune diseases, coeliac disease, glomerulonephritis, hepatitis, inflammatory bowel disease, preperfusion injury and transplant rejection.

Featured

Latest Research and Reviews

  • Research |

    Single-cell transcriptomics reveals immune and stromal compartment remodeling, including the enrichment of unique populations of epithelial cells and CD4+ T cells, in asthmatic lungs

    • Felipe A. Vieira Braga
    • , Gozde Kar
    • , Marijn Berg
    • , Orestes A. Carpaij
    • , Krzysztof Polanski
    • , Lukas M. Simon
    • , Sharon Brouwer
    • , Tomás Gomes
    • , Laura Hesse
    • , Jian Jiang
    • , Eirini S. Fasouli
    • , Mirjana Efremova
    • , Roser Vento-Tormo
    • , Carlos Talavera-López
    • , Marnix R. Jonker
    • , Karen Affleck
    • , Subarna Palit
    • , Paulina M. Strzelecka
    • , Helen V. Firth
    • , Krishnaa T. Mahbubani
    • , Ana Cvejic
    • , Kerstin B. Meyer
    • , Kourosh Saeb-Parsy
    • , Marjan Luinge
    • , Corry-Anke Brandsma
    • , Wim Timens
    • , Ilias Angelidis
    • , Maximilian Strunz
    • , Gerard H. Koppelman
    • , Antoon J. van Oosterhout
    • , Herbert B. Schiller
    • , Fabian J. Theis
    • , Maarten van den Berge
    • , Martijn C. Nawijn
    •  & Sarah A. Teichmann
  • Research |

    Exposure to a farm-like house dust microbiome is associated with protection against asthma development in children living in urban environments.

    • Pirkka V. Kirjavainen
    • , Anne M. Karvonen
    • , Rachel I. Adams
    • , Martin Täubel
    • , Marjut Roponen
    • , Pauli Tuoresmäki
    • , Georg Loss
    • , Balamuralikrishna Jayaprakash
    • , Martin Depner
    • , Markus Johannes Ege
    • , Harald Renz
    • , Petra Ina Pfefferle
    • , Bianca Schaub
    • , Roger Lauener
    • , Anne Hyvärinen
    • , Rob Knight
    • , Dick J. J. Heederik
    • , Erika von Mutius
    •  & Juha Pekkanen
  • Research |

    Here, the authors apply quantitative microbiome profiling to a metagenomics data set comprising patients with primary sclerosing cholangitis and/or inflammatory bowel disease and identify microbial taxa associated with inflammation or specific disease indicators, which were validated in an independent inflammatory bowel disease cohort.

    • Sara Vieira-Silva
    • , João Sabino
    • , Mireia Valles-Colomer
    • , Gwen Falony
    • , Gunter Kathagen
    • , Clara Caenepeel
    • , Isabelle Cleynen
    • , Schalk van der Merwe
    • , Séverine Vermeire
    •  & Jeroen Raes
  • Research | | open

    Men and women differ in their risk of developing coronary artery disease, in part due to differences in their levels of sex hormones. Here, AlSiraj et al. show that the XX sex genotype regulates lipid metabolism and promotes atherosclerosis independently of sex hormones in mice.

    • Yasir AlSiraj
    • , Xuqi Chen
    • , Sean E. Thatcher
    • , Ryan E. Temel
    • , Lei Cai
    • , Eric Blalock
    • , Wendy Katz
    • , Heba M. Ali
    • , Michael Petriello
    • , Pan Deng
    • , Andrew J. Morris
    • , Xuping Wang
    • , Aldons J. Lusis
    • , Arthur P. Arnold
    • , Karen Reue
    • , Katherine Thompson
    • , Patrick Tso
    •  & Lisa A. Cassis
  • Reviews |

    ST-segment elevation myocardial infarction (STEMI) is an acute coronary syndrome in which transmural ischaemia (mostly caused by the formation of a thrombus on a ruptured atherosclerotic plaque) leads to cardiomyocyte death. STEMI is associated with considerable morbidity and mortality worldwide.

    • Birgit Vogel
    • , Bimmer E. Claessen
    • , Suzanne V. Arnold
    • , Danny Chan
    • , David J. Cohen
    • , Evangelos Giannitsis
    • , C. Michael Gibson
    • , Shinya Goto
    • , Hugo A. Katus
    • , Mathieu Kerneis
    • , Takeshi Kimura
    • , Vijay Kunadian
    • , Duane S. Pinto
    • , Hiroki Shiomi
    • , John A. Spertus
    • , P. Gabriel Steg
    •  & Roxana Mehran

News and Comment