Inflammatory bowel disease

Inflammatory bowel disease is a chronic condition of unknown origin characterized by severe inflammation and mucosal destruction in the intestine. There are two main forms: Crohn’s disease, which can affect the entire gastrointestinal tract, but is most common in the colon and terminal ileum; and ulcerative colitis, which is a mucosal inflammation involving the rectum and colon.

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Latest Research and Reviews

  • Research |

    Here, the authors apply quantitative microbiome profiling to a metagenomics data set comprising patients with primary sclerosing cholangitis and/or inflammatory bowel disease and identify microbial taxa associated with inflammation or specific disease indicators, which were validated in an independent inflammatory bowel disease cohort.

    • Sara Vieira-Silva
    • , João Sabino
    • , Mireia Valles-Colomer
    • , Gwen Falony
    • , Gunter Kathagen
    • , Clara Caenepeel
    • , Isabelle Cleynen
    • , Schalk van der Merwe
    • , Séverine Vermeire
    •  & Jeroen Raes
  • Reviews | | open

    Over ten years, the Human Microbiome Project has provided resources for studying the microbiome and its relationship to disease; this Perspective summarizes the key achievements and findings of the project and its relationship to the broader field.

    • Lita M. Proctor
    • , Heather H. Creasy
    • , Jennifer M. Fettweis
    • , Jason Lloyd-Price
    • , Anup Mahurkar
    • , Wenyu Zhou
    • , Gregory A. Buck
    • , Michael P. Snyder
    • , Jerome F. Strauss III
    • , George M. Weinstock
    • , Owen White
    •  & Curtis Huttenhower
    Nature 569, 641-648
  • Research | | open

    The Inflammatory Bowel Disease Multi’omics Database includes longitudinal data encompassing a multitude of analyses of stool, blood and biopsies of more than 100 individuals, and provides a comprehensive description of host and microbial activities in inflammatory bowel diseases.

    • Jason Lloyd-Price
    • , Cesar Arze
    • , Ashwin N. Ananthakrishnan
    • , Melanie Schirmer
    • , Julian Avila-Pacheco
    • , Tiffany W. Poon
    • , Elizabeth Andrews
    • , Nadim J. Ajami
    • , Kevin S. Bonham
    • , Colin J. Brislawn
    • , David Casero
    • , Holly Courtney
    • , Antonio Gonzalez
    • , Thomas G. Graeber
    • , A. Brantley Hall
    • , Kathleen Lake
    • , Carol J. Landers
    • , Himel Mallick
    • , Damian R. Plichta
    • , Mahadev Prasad
    • , Gholamali Rahnavard
    • , Jenny Sauk
    • , Dmitry Shungin
    • , Yoshiki Vázquez-Baeza
    • , Richard A. White III
    • , Jason Bishai
    • , Kevin Bullock
    • , Amy Deik
    • , Courtney Dennis
    • , Jess L. Kaplan
    • , Hamed Khalili
    • , Lauren J. McIver
    • , Christopher J. Moran
    • , Long Nguyen
    • , Kerry A. Pierce
    • , Randall Schwager
    • , Alexandra Sirota-Madi
    • , Betsy W. Stevens
    • , William Tan
    • , Johanna J. ten Hoeve
    • , George Weingart
    • , Robin G. Wilson
    • , Vijay Yajnik
    • , Jonathan Braun
    • , Lee A. Denson
    • , Janet K. Jansson
    • , Rob Knight
    • , Subra Kugathasan
    • , Dermot P. B. McGovern
    • , Joseph F. Petrosino
    • , Thaddeus S. Stappenbeck
    • , Harland S. Winter
    • , Clary B. Clish
    • , Eric A. Franzosa
    • , Hera Vlamakis
    • , Ramnik J. Xavier
    •  & Curtis Huttenhower
    Nature 569, 655-662

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