Immunotherapy

Immunotherapy is the treatment of disease by inducing, enhancing or suppressing an immune response. Activation immunotherapies induce or amplify an immune response and are used in vaccines and as cancer immunotherapies. Suppression immunotherapies reduce or suppress an immune response and are used to prevent graft rejection and treat autoimmunity and allergy.

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Latest Research and Reviews

  • Research
    | Open Access

    Benitez et al. show that mice lacking the autoimmune regulator Aire, which is important for T cell central tolerance, show an improved anti-tumor response and expansion of T cell clones with high tumor reactivity after anti-PD1 antibody treatment compared to wild-type mice. This study suggests a path towards improved immunotherapy strategies.

    • Asiel A. Benitez
    • , Sara Khalil-Agüero
    • , Anjali Nandakumar
    • , Namita T. Gupta
    • , Wen Zhang
    • , Gurinder S. Atwal
    • , Andrew J. Murphy
    • , Matthew A. Sleeman
    •  & Sokol Haxhinasto
  • Reviews |

    The availability and subsequent successes of immune-checkpoint inhibitors (ICIs) in patients with metastatic melanoma, and to a lesser extent in those with several other forms of cancer, have made long-term treatment-free remissions a realistic possibility for a subset of patients. In this Perspective, the authors describe available data on long-term remission from patients with melanoma and other solid tumours and provide early recommendations regarding the circumstances in which ICIs can be safely discontinued.

    • Caroline Robert
    • , Aurelien Marabelle
    • , Hugo Herrscher
    • , Caroline Caramella
    • , Pascal Rouby
    • , Karim Fizazi
    •  & Benjamin Besse
  • Research |

    Huppa and colleagues highlight signaling deficiencies in chimeric antigen receptor (CAR)-modified T cells that limit the efficacy of CAR T cell therapies to target tumors with diminished antigen expression.

    • Venugopal Gudipati
    • , Julian Rydzek
    • , Iago Doel-Perez
    • , Vasco Dos Reis Gonçalves
    • , Lydia Scharf
    • , Sebastian Königsberger
    • , Elisabeth Lobner
    • , Renate Kunert
    • , Hermann Einsele
    • , Hannes Stockinger
    • , Michael Hudecek
    •  & Johannes B. Huppa
  • Research |

    Methotrexate-loaded tumour-cell-derived microvesicles induce neutrophil-mediated antitumour activity and can relieve biliary obstructions in patients with extrahepatic cholangiocarcinoma.

    • Yunfeng Gao
    • , Hui Zhang
    • , Nannan Zhou
    • , Pingwei Xu
    • , Jianxiong Wang
    • , Yuan Gao
    • , Xun Jin
    • , Xiaoyu Liang
    • , Jiadi Lv
    • , Yamin Zhang
    • , Ke Tang
    • , Jingwei Ma
    • , Huafeng Zhang
    • , Jing Xie
    • , Fang Yao
    • , Weimin Tong
    • , Yuying Liu
    • , Ximo Wang
    •  & Bo Huang
  • Reviews |

    This Review discusses our current understanding of adaptive and innate immune cell metabolism in the context of the tumour microenvironment, providing insight into the interaction of cancer cell metabolism and immune metabolism, as well as the potential for leveraging metabolic vulnerabilities to enhance the antitumour immune response.

    • Robert D. Leone
    •  & Jonathan D. Powell

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