Immunopathogenesis

Immunopathogenesis is the process of disease development involving an immune response or components thereof.

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  • Research | | open

    Orthobunyaviruses (OBVs) cause severe disease in humans and farm animals, but the molecular basis for infection is not fully understood. Here, the authors present crystal structures of free and antibody-bound OBV envelope glycoproteins and show that their domains enable efficient immunization in a mouse model.

    • Jan Hellert
    • , Andrea Aebischer
    • , Kerstin Wernike
    • , Ahmed Haouz
    • , Emiliana Brocchi
    • , Sven Reiche
    • , Pablo Guardado-Calvo
    • , Martin Beer
    •  & Félix A. Rey
  • Research | | open

    Immune activation induces long-term alterations of setpoints, impacting responses to subsequent unrelated stimuli. Here the authors show that volunteers vaccinated with BCG respond to controlled human malaria infection with increased clinical symptoms and an inverse correlation between immune activation markers and parasitemia.

    • Jona Walk
    • , L. Charlotte J. de Bree
    • , Wouter Graumans
    • , Rianne Stoter
    • , Geert-Jan van Gemert
    • , Marga van de Vegte-Bolmer
    • , Karina Teelen
    • , Cornelus C. Hermsen
    • , Rob J. W. Arts
    • , Marije C. Behet
    • , Farid Keramati
    • , Simone J. C. F. M. Moorlag
    • , Annie S. P. Yang
    • , Reinout van Crevel
    • , Peter Aaby
    • , Quirijn de Mast
    • , André J. A. M. van der Ven
    • , Christine Stabell Benn
    • , Mihai G. Netea
    •  & Robert W. Sauerwein
  • Research | | open

    Autoreactive T cells are suspected to destroy hypocretin-producing neurons in narcolepsy. Here the authors detect CD8 T cells recognizing narcolepsy-related proteins in healthy individuals and in patients with narcolepsy, and show that the frequency of self-reactive CD8 T cells differs between patients and controls sharing the same HLA-II risk allele.

    • Natasja Wulff Pedersen
    • , Anja Holm
    • , Nikolaj Pagh Kristensen
    • , Anne-Mette Bjerregaard
    • , Amalie Kai Bentzen
    • , Andrea Marion Marquard
    • , Tripti Tamhane
    • , Kristoffer Sølvsten Burgdorf
    • , Henrik Ullum
    • , Poul Jennum
    • , Stine Knudsen
    • , Sine Reker Hadrup
    •  & Birgitte Rahbek Kornum
  • Research |

    Stemness is crucial for the maintenance of long-term T cell memory. Gattinoni and colleagues demonstrate that the transcription factor c-Myb is essential for the establishment of a stemness program in the CD8+ T cell memory compartment.

    • Sanjivan Gautam
    • , Jessica Fioravanti
    • , Wei Zhu
    • , John B. Le Gall
    • , Philip Brohawn
    • , Neal E. Lacey
    • , Jinhui Hu
    • , James D. Hocker
    • , Nga Voong Hawk
    • , Veena Kapoor
    • , William G. Telford
    • , Devikala Gurusamy
    • , Zhiya Yu
    • , Avinash Bhandoola
    • , Hai-Hui Xue
    • , Rahul Roychoudhuri
    • , Brandon W. Higgs
    • , Nicholas P. Restifo
    • , Timothy P. Bender
    • , Yun Ji
    •  & Luca Gattinoni
    Nature Immunology 20, 337-349

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