Immunological memory

Immunological memory refers to the ability of the immune system to respond more rapidly and effectively to a pathogen that has been encountered previously.

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Latest Research and Reviews

  • Research |

    Stemness is crucial for the maintenance of long-term T cell memory. Gattinoni and colleagues demonstrate that the transcription factor c-Myb is essential for the establishment of a stemness program in the CD8+ T cell memory compartment.

    • Sanjivan Gautam
    • , Jessica Fioravanti
    • , Wei Zhu
    • , John B. Le Gall
    • , Philip Brohawn
    • , Neal E. Lacey
    • , Jinhui Hu
    • , James D. Hocker
    • , Nga Voong Hawk
    • , Veena Kapoor
    • , William G. Telford
    • , Devikala Gurusamy
    • , Zhiya Yu
    • , Avinash Bhandoola
    • , Hai-Hui Xue
    • , Rahul Roychoudhuri
    • , Brandon W. Higgs
    • , Nicholas P. Restifo
    • , Timothy P. Bender
    • , Yun Ji
    •  & Luca Gattinoni
    Nature Immunology 20, 337-349
  • Research |

    Cross-protective responses across all strains of influenza virus (IAV, IBV and ICV) are a key goal of universal vaccines against influenza. Kedzierska and colleagues identify cytotoxic T cells present in blood and lungs of healthy people that are directed against all strains of influenza virus.

    • Marios Koutsakos
    • , Patricia T. Illing
    • , Thi H. O. Nguyen
    • , Nicole A. Mifsud
    • , Jeremy Chase Crawford
    • , Simone Rizzetto
    • , Auda A. Eltahla
    • , E. Bridie Clemens
    • , Sneha Sant
    • , Brendon Y. Chua
    • , Chinn Yi Wong
    • , E. Kaitlynn Allen
    • , Don Teng
    • , Pradyot Dash
    • , David F. Boyd
    • , Ludivine Grzelak
    • , Weiguang Zeng
    • , Aeron C. Hurt
    • , Ian Barr
    • , Steve Rockman
    • , David C. Jackson
    • , Tom C. Kotsimbos
    • , Allen C. Cheng
    • , Michael Richards
    • , Glen P. Westall
    • , Thomas Loudovaris
    • , Stuart I. Mannering
    • , Michael Elliott
    • , Stuart G. Tangye
    • , Linda M. Wakim
    • , Jamie Rossjohn
    • , Dhanasekaran Vijaykrishna
    • , Fabio Luciani
    • , Paul G. Thomas
    • , Stephanie Gras
    • , Anthony W. Purcell
    •  & Katherine Kedzierska
  • Research | | open

    T cells express specific T cell receptors (TCR) to recognise antigens and initiate adaptive immune responses. Here the authors show, in a mouse model of autoimmune encephalomyelitis, that memory-like CD4 T cells expressing unrelated TCR can also infiltrate the spinal cord and contribute to autoimmunity.

    • Hong-Gyun Lee
    • , Jae-Ung Lee
    • , Do-Hyun Kim
    • , Sangho Lim
    • , Insoo Kang
    •  & Je-Min Choi
  • Research | | open

    Immune recognition of Influenza B virus (IBV) is poorly understood. Here, Liu et al. use flow cytometry to characterize IBV-specific memory B cell responses following seasonal vaccination and show that elicited cross-reactive antibodies can protect against infection, providing a platform for vaccine design.

    • Yi Liu
    • , Hyon-Xhi Tan
    • , Marios Koutsakos
    • , Sinthujan Jegaskanda
    • , Robyn Esterbauer
    • , Danielle Tilmanis
    • , Malet Aban
    • , Katherine Kedzierska
    • , Aeron C. Hurt
    • , Stephen J. Kent
    •  & Adam K. Wheatley
  • Research |

    ACC1 is a rate-limiting enzyme during fatty acid biosynthesis. Here the authors describe how loss of ACC1 enhances CD4+ memory T cell formation and improves outcome in a murine model of parasite infection, indicating that lipid biosynthesis directs cell-fate determination during the generation of memory T cells.

    • Yusuke Endo
    • , Atsushi Onodera
    • , Kazushige Obata-Ninomiya
    • , Ryo Koyama-Nasu
    • , Hikari K. Asou
    • , Toshihiro Ito
    • , Takeshi Yamamoto
    • , Toshio Kanno
    • , Takahiro Nakajima
    • , Kenji Ishiwata
    • , Hirotaka Kanuka
    • , Damon J. Tumes
    •  & Toshinori Nakayama
    Nature Metabolism 1, 261-275
  • Research | | open

    Mutations within immunological epitope containing regions of influenza A virus can impair the established immune response between influenza strains and could impact rational vaccine design. Here Grant et al. examine the presence, structural impact and cross reactivity of two human immunodominant influenza epitope variants.

    • Emma J. Grant
    • , Tracy M. Josephs
    • , Liyen Loh
    • , E. Bridie Clemens
    • , Sneha Sant
    • , Mandvi Bharadwaj
    • , Weisan Chen
    • , Jamie Rossjohn
    • , Stephanie Gras
    •  & Katherine Kedzierska

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