Immunogenetics

Immunogenetics is the study of the genetic basis of the immune response. It includes the study of normal immunological pathways and the identification of genetic variations that result in immune defects, which may result in the identification of new therapeutic targets for immune diseases.

Latest Research and Reviews

  • Research | | open

    The burden of asthma varies between ancestries, but GWAS have so far focused on mainly European ancestry populations. Here, Daya et al. perform GWAS for asthma in 14,654 individuals of African ancestry and, besides confirming previously known loci, identify two potentially African ancestry-specific loci.

    • Michelle Daya
    • , Nicholas Rafaels
    • , Tonya M. Brunetti
    • , Sameer Chavan
    • , Albert M. Levin
    • , Aniket Shetty
    • , Christopher R. Gignoux
    • , Meher Preethi Boorgula
    • , Genevieve Wojcik
    • , Monica Campbell
    • , Candelaria Vergara
    • , Dara G. Torgerson
    • , Victor E. Ortega
    • , Ayo Doumatey
    • , Henry Richard Johnston
    • , Nathalie Acevedo
    • , Maria Ilma Araujo
    • , Pedro C. Avila
    • , Gillian Belbin
    • , Eugene Bleecker
    • , Carlos Bustamante
    • , Luis Caraballo
    • , Alvaro Cruz
    • , Georgia M. Dunston
    • , Celeste Eng
    • , Mezbah U. Faruque
    • , Trevor S. Ferguson
    • , Camila Figueiredo
    • , Jean G. Ford
    • , Weiniu Gan
    • , Pierre-Antoine Gourraud
    • , Nadia N. Hansel
    • , Ryan D. Hernandez
    • , Edwin Francisco Herrera-Paz
    • , Silvia Jiménez
    • , Eimear E. Kenny
    • , Jennifer Knight-Madden
    • , Rajesh Kumar
    • , Leslie A. Lange
    • , Ethan M. Lange
    • , Antoine Lizee
    • , Pissamai Maul
    • , Trevor Maul
    • , Alvaro Mayorga
    • , Deborah Meyers
    • , Dan L. Nicolae
    • , Timothy D. O’Connor
    • , Ricardo Riccio Oliveira
    • , Christopher O. Olopade
    • , Olufunmilayo Olopade
    • , Zhaohui S. Qin
    • , Charles Rotimi
    • , Nicolas Vince
    • , Harold Watson
    • , Rainford J. Wilks
    • , James G. Wilson
    • , Steven Salzberg
    • , Carole Ober
    • , Esteban G. Burchard
    • , L. Keoki Williams
    • , Terri H. Beaty
    • , Margaret A. Taub
    • , Ingo Ruczinski
    • , Rasika A. Mathias
    • , Kathleen C. Barnes
    • , Ayola Akim Adegnika
    • , Ganiyu Arinola
    • , Ulysse Ateba-Ngoa
    • , Gerardo Ayestas
    • , Hilda Bjarnadóttir
    • , Adolfo Correa
    • , Said Omar Leiva Erazo
    • , Marilyn G. Foreman
    • , Cassandra Foster
    • , Li Gao
    • , Jingjing Gao
    • , Leslie Grammer
    • , Mark Hansen
    • , Tina Hartert
    • , Yijuan Hu
    • , Iain Königsberg
    • , Kwang-Youn A. Kim
    • , Pamela Landaverde-Torres
    • , Javier Marrugo
    • , Beatriz Martinez
    • , Rosella Martinez
    • , Luis F. Mayorga
    • , Delmy-Aracely Mejia-Mejia
    • , Catherine Meza
    • , Solomon Musani
    • , Shaila Musharoff
    • , Oluwafemi Oluwole
    • , Maria Pino-Yanes
    • , Hector Ramos
    • , Allan Saenz
    • , Maureen Samms-Vaughan
    • , Robert Schleimer
    • , Alan F. Scott
    • , Suyash S. Shringarpure
    • , Wei Song
    • , Zachary A. Szpiech
    • , Raul Torres
    • , Gloria Varela
    • , Olga Marina Vasquez
    • , Francisco M. De La Vega
    • , Lorraine B. Ware
    •  & Maria Yazdanbakhsh
  • Research | | open

    Dimitre Simeonov, Alexander Brandt et al. report a pathogenic bystander mutation caused by unintended repair of a CRISPR-Cas9-mediated deletion in mice. They generate mice lacking an IL2RA intronic enhancer previously associated with human disease risk and find that one line of edited mice show unexpected disease features due to a bystander mutation.

    • Dimitre R. Simeonov
    • , Alexander J. Brandt
    • , Alice Y. Chan
    • , Jessica T. Cortez
    • , Zhongmei Li
    • , Jonathan M. Woo
    • , Youjin Lee
    • , Claudia M. B. Carvalho
    • , Alyssa C. Indart
    • , Theodore L. Roth
    • , James Zou
    • , Andrew P. May
    • , James R. Lupski
    • , Mark S. Anderson
    • , F. William Buaas
    • , Daniel S. Rokhsar
    •  & Alexander Marson
  • Research |

    An intricately linked homeostasis exists between the gut microbiome and host immune system. Scheffold and colleagues show that intestinal Treg cells upregulate the transcription factor c-Maf in response to specific signals from the gut microenvironment to establish host–microbiota homeostasis.

    • Christian Neumann
    • , Jonas Blume
    • , Urmi Roy
    • , Peggy P. Teh
    • , Ajithkumar Vasanthakumar
    • , Alexander Beller
    • , Yang Liao
    • , Frederik Heinrich
    • , Teresita L. Arenzana
    • , Jason A. Hackney
    • , Celine Eidenschenk
    • , Eric J. C. Gálvez
    • , Christina Stehle
    • , Gitta A. Heinz
    • , Patrick Maschmeyer
    • , Tom Sidwell
    • , Yifang Hu
    • , Derk Amsen
    • , Chiara Romagnani
    • , Hyun-Dong Chang
    • , Andrey Kruglov
    • , Mir-Farzin Mashreghi
    • , Wei Shi
    • , Till Strowig
    • , Sascha Rutz
    • , Axel Kallies
    •  & Alexander Scheffold
  • Research |

    Many clonotypes in human B cell repertoires are shared, including between adult and umbilical cord blood repertoires, which indicates that this similarity is not driven only by exposure to common antigens.

    • Cinque Soto
    • , Robin G. Bombardi
    • , Andre Branchizio
    • , Nurgun Kose
    • , Pranathi Matta
    • , Alexander M. Sevy
    • , Robert S. Sinkovits
    • , Pavlo Gilchuk
    • , Jessica A. Finn
    •  & James E. Crowe Jr
    Nature 566, 398-402

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