Immunogenetics

Immunogenetics is the study of the genetic basis of the immune response. It includes the study of normal immunological pathways and the identification of genetic variations that result in immune defects, which may result in the identification of new therapeutic targets for immune diseases.

Latest Research and Reviews

  • Research | | open

    • Takashi Higuchi
    • , Shomi Oka
    • , Hiroshi Furukawa
    • , Minoru Nakamura
    • , Atsumasa Komori
    • , Seigo Abiru
    • , Satoru Hashimoto
    • , Masaaki Shimada
    • , Kaname Yoshizawa
    • , Hiroshi Kouno
    • , Atsushi Naganuma
    • , Keisuke Ario
    • , Toshihiko Kaneyoshi
    • , Haruhiro Yamashita
    • , Hironao Takahashi
    • , Fujio Makita
    • , Hiroshi Yatsuhashi
    • , Hiromasa Ohira
    •  & Kiyoshi Migita
  • Research | | open

    Function-altering variants of immune-related genes cause rare autoimmune syndromes, whereas their contribution to common autoimmune diseases remains uncharacterized. Here the authors show that rare variants of lupus-associated genes are present in the majority of lupus patients and healthy controls, but only the variants found in lupus patients alter gene function.

    • Simon H. Jiang
    • , Vicki Athanasopoulos
    • , Julia I. Ellyard
    • , Aaron Chuah
    • , Jean Cappello
    • , Amelia Cook
    • , Savit B. Prabhu
    • , Jacob Cardenas
    • , Jinghua Gu
    • , Maurice Stanley
    • , Jonathan A. Roco
    • , Ilenia Papa
    • , Mehmet Yabas
    • , Giles D. Walters
    • , Gaetan Burgio
    • , Kathryn McKeon
    • , James M. Byers
    • , Charlotte Burrin
    • , Anselm Enders
    • , Lisa A. Miosge
    • , Pablo F. Canete
    • , Marija Jelusic
    • , Velibor Tasic
    • , Adrian C. Lungu
    • , Stephen I. Alexander
    • , Arthur R. Kitching
    • , David A. Fulcher
    • , Nan Shen
    • , Todor Arsov
    • , Paul A. Gatenby
    • , Jeff J. Babon
    • , Dominic F. Mallon
    • , Carmen de Lucas Collantes
    • , Eric A. Stone
    • , Philip Wu
    • , Matthew A. Field
    • , Thomas D. Andrews
    • , Eun Cho
    • , Virginia Pascual
    • , Matthew C. Cook
    •  & Carola G. Vinuesa
  • Research | | open

    Streptococcus pneumoniae is a causative agent of meningitis and bacteremia. In a combined pathogen and host GWAS, Lees et al. find that host genetic variation is associated with both susceptibility and severity of pneumococcal meningitis, and specific bacterial genetic variation associated with susceptibility.

    • John A. Lees
    • , Bart Ferwerda
    • , Philip H. C. Kremer
    • , Nicole E. Wheeler
    • , Mercedes Valls Serón
    • , Nicholas J. Croucher
    • , Rebecca A. Gladstone
    • , Hester J. Bootsma
    • , Nynke Y. Rots
    • , Alienke J. Wijmega-Monsuur
    • , Elisabeth A. M. Sanders
    • , Krzysztof Trzciński
    • , Anne L. Wyllie
    • , Aeilko H. Zwinderman
    • , Leonard H. van den Berg
    • , Wouter van Rheenen
    • , Jan H. Veldink
    • , Zitta B. Harboe
    • , Lene F. Lundbo
    • , Lisette C. P. G. M. de Groot
    • , Natasja M. van Schoor
    • , Nathalie van der Velde
    • , Lars H. Ängquist
    • , Thorkild I. A. Sørensen
    • , Ellen A. Nohr
    • , Alexander J. Mentzer
    • , Tara C. Mills
    • , Julian C. Knight
    • , Mignon du Plessis
    • , Susan Nzenze
    • , Jeffrey N. Weiser
    • , Julian Parkhill
    • , Shabir Madhi
    • , Thomas Benfield
    • , Anne von Gottberg
    • , Arie van der Ende
    • , Matthijs C. Brouwer
    • , Jeffrey C. Barrett
    • , Stephen D. Bentley
    •  & Diederik van de Beek
  • Research | | open

    Systemic lupus erythematosus (SLE) shows a striking bias towards higher prevalence in females. Here, the authors perform fine-mapping of an SLE-associated locus at Xp21.2 and characterise a candidate gene, CXorf21, as IFN-responsive in immune cells that shows sexually dimorphic expression.

    • Christopher A. Odhams
    • , Amy L. Roberts
    • , Susan K. Vester
    • , Carolina S. T. Duarte
    • , Charlie T. Beales
    • , Alexander J. Clarke
    • , Sonja Lindinger
    • , Samuel J. Daffern
    • , Antonino Zito
    • , Lingyan Chen
    • , Leonardo L. Jones
    • , Lora Boteva
    • , David L. Morris
    • , Kerrin S. Small
    • , Michelle M. A. Fernando
    • , Deborah S. Cunninghame Graham
    •  & Timothy J. Vyse

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