Immunogenetics is the study of the genetic basis of the immune response. It includes the study of normal immunological pathways and the identification of genetic variations that result in immune defects, which may result in the identification of new therapeutic targets for immune diseases.

Latest Research and Reviews

News and Comment

  • News and Views |

    Severe allergic disease is common, and few monogenic causes of atopy have been described. A new study that convincingly links severe atopic dermatitis to heterozygous CARD11 mutations with dominant-interfering activity serves as a timely reminder that clinicians should consider the possibility of an underlying monogenic immune disorder when caring for patients suffering from severe allergic disease.

    • Catherine M Biggs
    • , Henry Y Lu
    •  & Stuart E Turvey
    Nature Genetics 49, 1162–1163
  • News and Views |

    A common ancestor of the modern codfish acquired a set of mutations that eliminated a major arm of the adaptive immune system—the MHC II pathway of antigen presentation to CD4+ T cells. Subsequent to this event, there was a radiation of these fish in which the number and diversity of MHC I genes increased in species-specific ways.

    • Peter Parham
    Nature Genetics 48, 1103–1104
  • News and Views |

    Iron is essential in multiple cellular processes and is especially critical for cellular respiration and division. A new study identified a mutation affecting the iron import receptor TfR1 as the cause of a human primary immunodeficiency, illuminating the importance of iron in immune cell function.

    • Bernice Lo
    Nature Genetics 48, 10–11
  • News and Views |

    Immature B lymphocytes and T lymphocytes assemble antigen receptor–encoding genes in lineage- and developmental stage–specific fashion. New findings show that pre-B cells use specialized locus-specific epigenetic mechanisms to promote recombination of the locus encoding the immunoglobulin κ-chain (Igk) and κ-chain+ B cell development.

    • Megan R Fisher
    •  & Craig H Bassing
    Nature Immunology 16, 1007–1009