Immunoediting

Definition

Immunoediting is a term used to describe the evolution of tumours such that the tumour cells are no longer effectively recognised and killed by the immune system.

Latest Research and Reviews

  • Research |

    CMTM6 maintains PD-L1 at the plasma membrane by inhibiting its lysosome-mediated degradation and promoting its recycling.

    • Marian L. Burr
    • , Christina E. Sparbier
    • , Yih-Chih Chan
    • , James C. Williamson
    • , Katherine Woods
    • , Paul A. Beavis
    • , Enid Y. N. Lam
    • , Melissa A. Henderson
    • , Charles C. Bell
    • , Sabine Stolzenburg
    • , Omer Gilan
    • , Stuart Bloor
    • , Tahereh Noori
    • , David W. Morgens
    • , Michael C. Bassik
    • , Paul J. Neeson
    • , Andreas Behren
    • , Phillip K. Darcy
    • , Sarah-Jane Dawson
    • , Ilia Voskoboinik
    • , Joseph A. Trapani
    • , Jonathan Cebon
    • , Paul J. Lehner
    •  & Mark A. Dawson
    Nature 549, 101–105
  • Research | | open

    Loss of major histocompatibility complex MHC-I expression contributes to cancer immune evasion. Here, the authors show that, in both mice and humans, MHC-I downregulation is associated with the induction of NK-cell exhaustion and that IL-21 restores NK-cell function and inhibits tumours progression.

    • Hyungseok Seo
    • , Insu Jeon
    • , Byung-Seok Kim
    • , Myunghwan Park
    • , Eun-Ah Bae
    • , Boyeong Song
    • , Choong-Hyun Koh
    • , Kwang-Soo Shin
    • , Il-Kyu Kim
    • , Kiyoung Choi
    • , Taegwon Oh
    • , Jiyoun Min
    • , Byung Soh Min
    • , Yoon Dae Han
    • , Suk-Jo Kang
    • , Sang Joon Shin
    • , Yeonseok Chung
    •  & Chang-Yuil Kang
  • Research | | open

    IFNγ secretion by CD8+ T cells is critical for immunotherapy efficacy. In this study, the authors show that melanoma patients can become resistant to immunotherapy by acquiring chromosomal alterations and subsequent inactivating mutations in genes of the IFNγ signalling cascade, most often JAK1 or JAK2.

    • Antje Sucker
    • , Fang Zhao
    • , Natalia Pieper
    • , Christina Heeke
    • , Raffaela Maltaner
    • , Nadine Stadtler
    • , Birgit Real
    • , Nicola Bielefeld
    • , Sebastian Howe
    • , Benjamin Weide
    • , Ralf Gutzmer
    • , Jochen Utikal
    • , Carmen Loquai
    • , Helen Gogas
    • , Ludger Klein-Hitpass
    • , Michael Zeschnigk
    • , Astrid M. Westendorf
    • , Mirko Trilling
    • , Susanne Horn
    • , Bastian Schilling
    • , Dirk Schadendorf
    • , Klaus G. Griewank
    •  & Annette Paschen
  • Research |

    Interferon-γ acts on tumour endothelial cells to drive vascular regression, inducing ischaemia that leads to tumour collapse.

    • Thomas Kammertoens
    • , Christian Friese
    • , Ainhoa Arina
    • , Christian Idel
    • , Dana Briesemeister
    • , Michael Rothe
    • , Andranik Ivanov
    • , Anna Szymborska
    • , Giannino Patone
    • , Severine Kunz
    • , Daniel Sommermeyer
    • , Boris Engels
    • , Matthias Leisegang
    • , Ana Textor
    • , Hans Joerg Fehling
    • , Marcus Fruttiger
    • , Michael Lohoff
    • , Andreas Herrmann
    • , Hua Yu
    • , Ralph Weichselbaum
    • , Wolfgang Uckert
    • , Norbert Hübner
    • , Holger Gerhardt
    • , Dieter Beule
    • , Hans Schreiber
    •  & Thomas Blankenstein
    Nature 545, 98–102

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