Immunization

Definition

Immunization is the deliberation stimulation of the host's immune system to protect the host from a disease. Active immunization involves the administration of an immunogen to render the host more responsive to a subsequent encounter. Passive immunization involves the transfer of immune components, such as antibodies or lymphocytes, or of immune-cell-producing tissues.

Latest Research and Reviews

  • Research | | open

    Circulating memory cells include central memory T cells retaining the ability to enter the lymph nodes whereas tissue resident memory cells are confined to the parenchymal tissues. Here the authors explore the interplay between the two T-cell types and show that both cooperate in anti-tumour immunity.

    • Michel Enamorado
    • , Salvador Iborra
    • , Elena Priego
    • , Francisco J. Cueto
    • , Juan A. Quintana
    • , Sarai Martínez-Cano
    • , Ernesto Mejías-Pérez
    • , Mariano Esteban
    • , Ignacio Melero
    • , Andrés Hidalgo
    •  & David Sancho
  • Research |

    The authors report the first-in-human application of personalized neo-antigen RNA vaccines in patients with melanoma.

    • Ugur Sahin
    • , Evelyna Derhovanessian
    • , Matthias Miller
    • , Björn-Philipp Kloke
    • , Petra Simon
    • , Martin Löwer
    • , Valesca Bukur
    • , Arbel D. Tadmor
    • , Ulrich Luxemburger
    • , Barbara Schrörs
    • , Tana Omokoko
    • , Mathias Vormehr
    • , Christian Albrecht
    • , Anna Paruzynski
    • , Andreas N. Kuhn
    • , Janina Buck
    • , Sandra Heesch
    • , Katharina H. Schreeb
    • , Felicitas Müller
    • , Inga Ortseifer
    • , Isabel Vogler
    • , Eva Godehardt
    • , Sebastian Attig
    • , Richard Rae
    • , Andrea Breitkreuz
    • , Claudia Tolliver
    • , Martin Suchan
    • , Goran Martic
    • , Alexander Hohberger
    • , Patrick Sorn
    • , Jan Diekmann
    • , Janko Ciesla
    • , Olga Waksmann
    • , Alexandra-Kemmer Brück
    • , Meike Witt
    • , Martina Zillgen
    • , Andree Rothermel
    • , Barbara Kasemann
    • , David Langer
    • , Stefanie Bolte
    • , Mustafa Diken
    • , Sebastian Kreiter
    • , Romina Nemecek
    • , Christoffer Gebhardt
    • , Stephan Grabbe
    • , Christoph Höller
    • , Jochen Utikal
    • , Christoph Huber
    • , Carmen Loquai
    •  & Özlem Türeci
    Nature 547, 222–226
  • Research | | open

    Tumour-specific T cells can be expanded in vitro and adoptively transferred for therapy, but this strategy is limited by induction of short-lived T cell populations. Here the authors activate Notch signalling in cultured mouse or human T cells, resulting in the production of a long-lived stem cell memory T cell population that can fight tumours in mice.

    • Taisuke Kondo
    • , Rimpei Morita
    • , Yuumi Okuzono
    • , Hiroko Nakatsukasa
    • , Takashi Sekiya
    • , Shunsuke Chikuma
    • , Takashi Shichita
    • , Mitsuhiro Kanamori
    • , Masato Kubo
    • , Keiko Koga
    • , Takahiro Miyazaki
    • , Yoshiaki Kassai
    •  & Akihiko Yoshimura
  • Research |

    Interferon-γ acts on tumour endothelial cells to drive vascular regression, inducing ischaemia that leads to tumour collapse.

    • Thomas Kammertoens
    • , Christian Friese
    • , Ainhoa Arina
    • , Christian Idel
    • , Dana Briesemeister
    • , Michael Rothe
    • , Andranik Ivanov
    • , Anna Szymborska
    • , Giannino Patone
    • , Severine Kunz
    • , Daniel Sommermeyer
    • , Boris Engels
    • , Matthias Leisegang
    • , Ana Textor
    • , Hans Joerg Fehling
    • , Marcus Fruttiger
    • , Michael Lohoff
    • , Andreas Herrmann
    • , Hua Yu
    • , Ralph Weichselbaum
    • , Wolfgang Uckert
    • , Norbert Hübner
    • , Holger Gerhardt
    • , Dieter Beule
    • , Hans Schreiber
    •  & Thomas Blankenstein
    Nature 545, 98–102

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