Immune cell death

Immune cell death is the process by which an immune cell undergoes cell death. There are various types of cell death mediated by intracellular programmes or external factors including apoptosis, necrosis, pyroptosis and necroptosis.

Latest Research and Reviews

News and Comment

  • Research Highlights |

    The long-term survival of HIV-1-infected CD4+ T cells is shown to be controlled by the anti-apoptotic protein BIRC5 and its upstream regulator OX40, which suggests new therapeutic targets to reduce the size of the viral reservoir.

    • Kirsty Minton
  • News and Views |

    Genetic integration of a humanized chemotaxis receptor unexpectedly reveals that a widely expressed immune protein is targeted by Staphylococcus aureus Panton–Valentine leukocidin in a novel way, changing our fundamental understanding of toxin–receptor biology and host–pathogen interaction.

    • Brandon Lee
    •  & Juliane Bubeck Wardenburg
    Nature Microbiology 3, 644-645
  • News and Views |

    The Streptococcus pyogenes surface M protein is a critical multifunctional virulence factor. Recent work sheds light on a new unexpected function of the M protein in activating the host inflammasome to induce macrophage cell death and promote infection.

    • Madeleine W. Cunningham
    Nature Microbiology 2, 1334-1335
  • News and Views |

    The ability to expand and contract populations of myeloid and lymphoid cells during emergency hematopoiesis helps shape the immune response. The expression of intracellular and soluble forms of osteopontin regulates apoptosis thresholds differently in myeloid cells and lymphoid cells to counter infection.

    • Motti Gerlic
    •  & Ben A Croker
    Nature Immunology 18, 953-954