Hydrocephalus refers to the medical condition in which an excessive amount of cerebrospinal fluid accumulates within the cranium. It often results in enlarged cerebral ventricles and increased intracranial pressure, which can be fatal.

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News and Comment

  • News and Views |

    Hydrocephalus describes an expansion of the cerebral ventricles that is associated with decreased cerebral volume and compromised neurological function. Although hydrocephalus mostly occurs sporadically, it is frequently associated with diseases caused by defective cilia function, including Bardet–Biedl syndrome (BBS). A new study reveals that hydrocephalus in a mouse model of BBS is related to defective proliferation and apoptosis of neural progenitor cells (NPCs) and can be rescued with lithium treatment (pages 1797–1804).

    • Bethany N Sotak
    •  & Joseph G Gleeson
    Nature Medicine 18, 1742–1743
  • Comments and Opinion |

    Practicing clinicians can experience difficulty in differentiating between Parkinson disease and idiopathic normal pressure hydrocephalus. In this article, Morishita and colleagues consider the clinical features that might differentiate Parkinson disease from idiopathic normal pressure hydrocephalus, and highlight the usefulness of the levodopa challenge test in distinguishing between these two conditions.

    • Takashi Morishita
    • , Kelly D. Foote
    •  & Michael S. Okun