Humoral immunity

Humoral immunity refers to antibody-mediated immune responses. Antibodies are produced by plasma cells and protect the host from infection in three main ways: by binding to pathogens to inhibit their toxic effects or infectivity (neutralization), by coating pathogens and facilitating their uptake and killing by phagocytes (opsonization) and by activating the complement cascade.

Latest Research and Reviews

  • Research |

    In a mouse model of herpes simplex 2 virus infection, circulating memory B cells—rather than plasma cells—are shown to be the source of antibody secretion in the vaginal lumen following secondary infection.

    • Ji Eun Oh
    • , Norifumi Iijima
    • , Eric Song
    • , Peiwen Lu
    • , Jonathan Klein
    • , Ruoyi Jiang
    • , Steven H. Kleinstein
    •  & Akiko Iwasaki
    Nature, 1-5
  • Research | | open

    Phosphatase of regenerating liver 3 (PRL3) is usually found intracellularly, and is over-expressed in cancer cells. Here the authors show that PRL-3 is also detectable on cell surface, and can be recognized by PRL3-zumab to recruit immune cells into tumor to promote anti-tumor immunity, thereby implicating PRL-3 as a potential tumor antigen.

    • Min Thura
    • , Abdul Qader Al-Aidaroos
    • , Abhishek Gupta
    • , Cheng Ean Chee
    • , Soo Chin Lee
    • , Kam Man Hui
    • , Jie Li
    • , Yeoh Khay Guan
    • , Wei Peng Yong
    • , Jimmy So
    • , Wee Joo Chng
    • , Chin Hin Ng
    • , Jianbiao Zhou
    • , Ling Zhi Wang
    • , John Shyi Peng Yuen
    • , Henry Sun Sien Ho
    • , Sim Mei Yi
    • , Edmund Chiong
    • , Su Pin Choo
    • , Joanne Ngeow
    • , Matthew Chau Hsien Ng
    • , Clarinda Chua
    • , Eugene Shen Ann Yeo
    • , Iain Bee Huat Tan
    • , Joel Xuan En Sng
    • , Nicholas Yan Zhi Tan
    • , Jean Paul Thiery
    • , Boon Cher Goh
    •  & Qi Zeng
  • Research | | open

    Gut lumen antigens must be continuously sampled by the immune system to maintain proper immune homeostasis. Here the authors show that activated CCR6+CCR1+GL7- gut B cells retrieve lumen antigens from specialized M cells and transfer them across the subepithelial dome in the Peyer’s patch to contribute to the maintenance of gut humoral immunity.

    • Rathan Joy Komban
    • , Anneli Strömberg
    • , Adi Biram
    • , Jakob Cervin
    • , Cristina Lebrero-Fernández
    • , Neil Mabbott
    • , Ulf Yrlid
    • , Ziv Shulman
    • , Mats Bemark
    •  & Nils Lycke
  • Research |

    Study of influenza virus transmission in humans provides evidence that hemagglutinin stalk-specific antibodies correlate with protection from infection.

    • Sophia Ng
    • , Raffael Nachbagauer
    • , Angel Balmaseda
    • , Daniel Stadlbauer
    • , Sergio Ojeda
    • , Mayuri Patel
    • , Arvind Rajabhathor
    • , Roger Lopez
    • , Andrea F. Guglia
    • , Nery Sanchez
    • , Fatima Amanat
    • , Lionel Gresh
    • , Guillermina Kuan
    • , Florian Krammer
    •  & Aubree Gordon
    Nature Medicine 25, 962-967
  • Research | | open

    Stabilized, native-like trimers of the HIV envelope protein, such as SOSIP trimers, are potential antigens for an HIV vaccine. Here, the authors generate a SOSIP trimer based on the consensus sequence of group M isolates, determine its structure and exposure of common epitopes, and show immunogenicity in rabbits and non-human primates.

    • Kwinten Sliepen
    • , Byung Woo Han
    • , Ilja Bontjer
    • , Petra Mooij
    • , Fernando Garces
    • , Anna-Janina Behrens
    • , Kimmo Rantalainen
    • , Sonu Kumar
    • , Anita Sarkar
    • , Philip J. M. Brouwer
    • , Yuanzi Hua
    • , Monica Tolazzi
    • , Edith Schermer
    • , Jonathan L. Torres
    • , Gabriel Ozorowski
    • , Patricia van der Woude
    • , Alba Torrents de la Peña
    • , Mariëlle J. van Breemen
    • , Juan Miguel Camacho-Sánchez
    • , Judith A. Burger
    • , Max Medina-Ramírez
    • , Nuria González
    • , Jose Alcami
    • , Celia LaBranche
    • , Gabriella Scarlatti
    • , Marit J. van Gils
    • , Max Crispin
    • , David C. Montefiori
    • , Andrew B. Ward
    • , Gerrit Koopman
    • , John P. Moore
    • , Robin J. Shattock
    • , Willy M. Bogers
    • , Ian A. Wilson
    •  & Rogier W. Sanders

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