HTLV

Definition

HTLV (human T-cell lymphotropic virus) is an infectious agent belonging to the virus family Retroviridae that is spread through contact with bodily fluids and causes a persistent infection in humans. It is associated with a number of pathologies, including adult T-cell leukaemia.

Latest Research and Reviews

  • Research | | open

    HTLV-1 predominantly spreads through direct cell-cell contacts, but mechanisms of target cell recruitment are unclear. Here, the authors show that HTLV-1 infected T-cells secrete leukotriene B4, which recruits T-cells, facilitates HTLV-1 transmission in vitro, and increases the number of infected clones in mice.

    • Florent Percher
    • , Céline Curis
    • , Eléonore Pérès
    • , Maria Artesi
    • , Nicolas Rosewick
    • , Patricia Jeannin
    • , Antoine Gessain
    • , Olivier Gout
    • , Renaud Mahieux
    • , Pierre-Emmanuel Ceccaldi
    • , Anne Van den Broeke
    • , Madeleine Duc Dodon
    •  & Philippe V. Afonso
  • Reviews |

    Human T-lymphotropic virus 1 (HTLV-1) infection can cause inflammation and degeneration of the spinal cord — HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Here, Bangham et al. summarize the pathogenesis and clinical management of this devastating disease and highlight open research questions.

    • Charles R. M. Bangham
    • , Abelardo Araujo
    • , Yoshihisa Yamano
    •  & Graham P. Taylor