HTLV (human T-cell lymphotropic virus) is an infectious agent belonging to the virus family Retroviridae that is spread through contact with bodily fluids and causes a persistent infection in humans. It is associated with a number of pathologies, including adult T-cell leukaemia.

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  • Reviews |

    Human T-lymphotropic virus 1 (HTLV-1) infection can cause inflammation and degeneration of the spinal cord — HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Here, Bangham et al. summarize the pathogenesis and clinical management of this devastating disease and highlight open research questions.

    • Charles R. M. Bangham
    • , Abelardo Araujo
    • , Yoshihisa Yamano
    •  & Graham P. Taylor