Histology is the study of the microscopic anatomy or structure of tissues.

Latest Research and Reviews

  • Reviews |

    The clinical relevance of variant histology in urinary bladder cancer has been increasing, resulting in new classifications of urothelial cancers by the WHO in 2016 and highlighting the importance of an accurate morphological description of pathological specimens for the therapeutic management of patients with bladder cancer.

    • Marco Moschini
    • , David D'Andrea
    • , Stephan Korn
    • , Yasin Irmak
    • , Francesco Soria
    • , Eva Compérat
    •  & Shahrokh F. Shariat
  • Reviews |

    High-grade prostatic intraepithelial neoplasia (HGPIN) and atypical glands suspicious for carcinoma are two prostate cancer diagnoses without standardized follow up and treatment pathways. In this Review, Tosoian and colleagues describe data that have shed light on these phenomena. The improved understanding of the implications of the presence of HGPIN and atypical glands on prostate biopsy means that clinical recommendations can be made for the management of patients with these diagnoses.

    • Jeffrey J. Tosoian
    • , Ridwan Alam
    • , Mark W. Ball
    • , H. Ballentine Carter
    •  & Jonathan I. Epstein
  • Research |

    Bradley Bernstein, Birgit Knoechel and colleagues identify super-enhancer translocations that drive overexpression of MYB in adenoid cystic carcinoma (ACC). They find that MYB binds to the translocated enhancers and to other active enhancers that drive different regulatory programs in alternate cell lineages in ACC.

    • Yotam Drier
    • , Matthew J Cotton
    • , Kaylyn E Williamson
    • , Shawn M Gillespie
    • , Russell J H Ryan
    • , Michael J Kluk
    • , Christopher D Carey
    • , Scott J Rodig
    • , Lynette M Sholl
    • , Amir H Afrogheh
    • , William C Faquin
    • , Lurdes Queimado
    • , Jun Qi
    • , Michael J Wick
    • , Adel K El-Naggar
    • , James E Bradner
    • , Christopher A Moskaluk
    • , Jon C Aster
    • , Birgit Knoechel
    •  & Bradley E Bernstein
    Nature Genetics 48, 265–272
  • Reviews |

    Mucinous colorectal cancer has, in the past, been associated with inferior responses to treatment, and worse patient outcomes compared with other colorectal cancer subtypes; although, this situation has improved in the past 10–15 years. In this Review, the authors describe the key developments that have enabled these improvements, in addition to the potential for further improvements in the care of patients with mucinous colorectal cancer.

    • Niek Hugen
    • , Gina Brown
    • , Robert Glynne-Jones
    • , Johannes H. W. de Wilt
    •  & Iris D. Nagtegaal

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