Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
The hippocampus is a forebrain structure located within the medial temporal lobe that consists of the subiculum, CA1, CA2, CA3 and dentate gyrus regions. The hippocampal formation also includes the entorhinal cortex. As part of the limbic system, the hippocampus is involved in memory encoding and storage.
Learning results in persistent double-stranded DNA breaks, nuclear rupture and release of DNA fragments and histones within hippocampal CA1 neurons that, following TLR9-mediated DNA damage repair, results in their recruitment to memory circuits.
Current approaches possibly cannot unambiguously distinguish the unique contributions of feedback inhibition versus feedforward inhibition to oscillatory events. Here authors show that a loss of CA1 pyramidal cell transmission, resulting in feedback inhibition reduction, leads to spatially triggered high-frequency oscillatory events; these events were like place cells in their spatial extent and localized to small regions in CA1.
The mechanisms regulating mitochondrial architecture in neurons remain unclear. The authors report that in dendrites, mitochondria structure is specified by the CAMKK2-AMPK pathway through compartment-specific and activity-dependent levels of fission.
A structural MRI study suggests that regular exercise training induces plasticity in hippocampal subregions also in young adults. Hippocampal plasticity correlates with changes in spatial memory precision.
Introducing machine-learning models for cross-species detection and analysis of hippocampal ripple oscillations, this userfriendly open-source toolbox streamlines standardized research and biomedical applications.
A mark test of self-recognition in mice reveals that self-responding ventral CA1 neurons underlie mirror-induced self-directed behaviour and are shaped by social experience with conspecifics.
In mice, localized mutant APP expression in the CA3 hippocampal region leads to progressive network dysfunction and hippocampus-dependent memory deficits.
A study reports that in the mouse hippocampus, the induction of long-term potentiation is dependent on the structural functions of CaMKII and not its enzymatic activity.