HIPPO signalling articles from across Nature Portfolio

Imbalance in the growth rate of two organs can perturb their appropriate scaling. Here, Stojanovski et al., identify a mechanism involving the mechanotransducer YAP-1 which ensures proper proportions of the pharynx and the body length of C. elegans.

YAP activation is a key driver in both malignant pleural mesothelioma and uveal melanoma through engagement of different regulatory elements. Here, the authors use functional epigenomic analyses to reveal lineage-specific YAP-dependent cistrome.

Kaneshige et al. show that skeletal muscle-resident mesenchymal progenitors relay the mechanical signal of muscle overload to muscle stem cells to induce their proliferation.

Liu et al. show that glycogen accumulates in pre-malignant liver cells by undergoing liquid–liquid phase separation and, by sequestering Hippo kinases MST1 and MST2, promotes YAP-driven tumorigenesis.

A new study shows that gene therapy to knock down endogenous Hippo signalling in cardiomyocytes induces cardiac tissue renewal and improves heart function after myocardial infarction in adult pigs.

A new study shows that crosstalk between the ERBB2 and Hippo–YAP pathways is required for robust cardiac regeneration after myocardial infarction. ERBB2–ERK–YAP mechanotransduction signalling and epithelial–mesenchymal transition-like processes in cardiomyocytes can trigger regeneration even after functional deterioration and scarring.

YAP and TAZ, paralogous mammalian genes, act as the key transcriptional effectors of the Hippo pathway. Two recent reports show that both YAP and TAZ form liquid–liquid phase-separated bodies that promote gene transcription by engaging in super-enhancers.