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Acetaminophen-induced liver injury is one of the most common causes of liver failure and has to be treated within hours of the overdose. Here Barbier-Torres et al. show that targeting MCJ, a mitochondrial negative regulator, even 24 h after the overdose protects liver from acetaminophen-induced damage.
In an article published recently in Nature Medicine, the authors generate organoid models of liver neoplasia. In doing so, they highlight both the diversity of current organoid methodologies and their application to cancer modeling and therapeutics discovery.
New research published in Nature now demonstrates that immune checkpoint blockade can alleviate hepatocellular carcinoma progression in patients with nonalcoholic steatohepatitis (NASH) by inhibiting immunosuppressive immunoglobulin A-producing cells in the liver.