Hepatitis C virus

Hepatitis C virus is an infectious agent that causes hepatitis C, a type of liver inflammation in humans. This virus species leads to chronic infection and severe complications such as liver cirrhosis or cancer more often than some of the other hepatitis viruses.

Latest Research and Reviews

  • Research | | open

    Organs from donors with transmissible viral infections, such as hepatitis C virus (HCV), are not offered for transplantation due to a high risk of transmission. Here, Galasso et al. develop a method for treatment of HCV-infected human donor lungs that is safe and prevents HCV transmission in the pig model.

    • Marcos Galasso
    • , Jordan J. Feld
    • , Yui Watanabe
    • , Mauricio Pipkin
    • , Cara Summers
    • , Aadil Ali
    • , Robert Qaqish
    • , Manyin Chen
    • , Rafaela V. P. Ribeiro
    • , Khaled Ramadan
    • , Layla Pires
    • , Vanderlei S. Bagnato
    • , Cristina Kurachi
    • , Vera Cherepanov
    • , Gray Moonen
    • , Anajara Gazzalle
    • , Thomas K. Waddell
    • , Mingyao Liu
    • , Shaf Keshavjee
    • , Brian C. Wilson
    • , Atul Humar
    •  & Marcelo Cypel
  • Research | | open

    The circadian clock can affect pathogen replication, but underlying molecular mechanisms are unclear. Here the authors demonstrate that the circadian components BMAL1 and REV-ERBα affect entry of hepatitis C virus (HCV) into hepatocytes and genome replication of HCV and related flaviviruses dengue and zika.

    • Xiaodong Zhuang
    • , Andrea Magri
    • , Michelle Hill
    • , Alvina G. Lai
    • , Abhinav Kumar
    • , Srinivasa Bhargav Rambhatla
    • , Claire L. Donald
    • , Andrea F. Lopez-Clavijo
    • , Simon Rudge
    • , Katherine Pinnick
    • , Wai Hoong Chang
    • , Peter A. C. Wing
    • , Ryan Brown
    • , Ximing Qin
    • , Peter Simmonds
    • , Thomas F. Baumert
    • , David Ray
    • , Andrew Loudon
    • , Peter Balfe
    • , Michael Wakelam
    • , Sam Butterworth
    • , Alain Kohl
    • , Catherine L. Jopling
    • , Nicole Zitzmann
    •  & Jane A. McKeating
  • Research |

    Hepatitis C virus (HCV) infection blunts induction of hepcidin expression by bone morphogenetic protein 6 (BMP6), probably via TNF-mediated downregulation of the BMP co-receptor HJV, while BMP6 regulates a gene repertoire reminiscent of type I IFN signalling. BMP6 and related activin proteins potently block replication of HCV, hepatitis B virus and Zika virus independently of IFN.

    • Lucy A. Eddowes
    • , Kinda Al-Hourani
    • , Narayan Ramamurthy
    • , Jamie Frankish
    • , Hannah T Baddock
    • , Cynthia Sandor
    • , John D. Ryan
    • , Dahlene N. Fusco
    • , João Arezes
    • , Eleni Giannoulatou
    • , Sara Boninsegna
    • , Stephane Chevaliez
    • , Benjamin M. J. Owens
    • , Chia Chi Sun
    • , Paolo Fabris
    • , Maria Teresa Giordani
    • , Diego Martines
    • , Slobodan Vukicevic
    • , John Crowe
    • , Herbert Y. Lin
    • , Jan Rehwinkel
    • , Peter J. McHugh
    • , Marco Binder
    • , Jodie L. Babitt
    • , Raymond T. Chung
    • , Matthew W. Lawless
    • , Andrew E. Armitage
    • , Caleb Webber
    • , Paul Klenerman
    •  & Hal Drakesmith
    Nature Microbiology 4, 339-351

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