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Establishing suitable outcome measures is an important goal for the classification and monitoring of patients with early knee osteoarthritis. This Perspectives article highlights various outcome measures that have potential use in clinical and/or research settings for early knee osteoarthritis.
We produced a human recombinant Hsp70-1A fused with the cell-penetrating peptide Tat (Tat-Hsp70-1A), that was neuroprotective in vitro against the dopaminergic toxin 6-hydroxydopamine (6-OHDA). We developed and characterized a Tat-Hsp70-1A delivery system by exploiting an injectable, biocompatible, biodegradable semi-interpenetrating polymer network composed of collagen (COLL) and low-molecular-weight hyaluronic acid (LMW HA), structured with gelatin particles. Tat-Hsp70-1A diffused from the selected COLL-LMW HA composites in an active form and protected dopaminergic cells and neurons in Parkinson’s disease (PD) models. Furthermore, Tat-Hsp70-loaded composites conveyed neuroprotection both at behavioral and dopaminergic neuronal level against striatal injection of 6-OHDA.
Lifestyle interventions in patients with prediabetes can delay the onset of type 2 diabetes mellitus, but long-term data on diabetes complications are lacking. A new report from the Da Qing Study provides data on the effect of lifestyle interventions on diabetes mellitus complications and mortality in patients with prediabetes who were followed up for 30 years.
The diagnostic reach of nonalcoholic fatty liver disease (NAFLD) is broad, stretching from simple steatosis to cirrhosis. Expanded disease definitions are an important cause of waste in health care. Now is the time to revise the definition of NAFLD to include only those who have developed advanced fibrosis.