Health care

Definition

Health care is the discipline concerned with the provision and delivery of health services to a patient population by personnel in professional and allied health occupations.

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Latest Research and Reviews

  • Reviews |

    Chronic kidney disease (CKD) is the progressive, irreversible loss of renal function that has many causes and contributing factors. In this Primer, the authors describe the many consequences of CKD and how understanding — and treating — the underlying cause can substantially slow CKD progression.

    • Paola Romagnani
    • , Giuseppe Remuzzi
    • , Richard Glassock
    • , Adeera Levin
    • , Kitty J. Jager
    • , Marcello Tonelli
    • , Ziad Massy
    • , Christoph Wanner
    •  & Hans-Joachim Anders
  • Research | | open

    Tumors often develop resistance to radiotherapy. Here the authors show that irradiation leads to a CCR2-dependent infiltration by myeloid derived suppressor cells that promote radio-resistance through inhibition of adaptive immune responses and that the use of CCR2 antibodies in mice reduces such resistance.

    • Hua Liang
    • , Liufu Deng
    • , Yuzhu Hou
    • , Xiangjiao Meng
    • , Xiaona Huang
    • , Enyu Rao
    • , Wenxin Zheng
    • , Helena Mauceri
    • , Matthias Mack
    • , Meng Xu
    • , Yang-Xin Fu
    •  & Ralph R. Weichselbaum
  • Research | | open

    The current FDA-approved whole blood stabilization method for circulating tumor cell (CTC) isolation suffers from RNA degradation. Here the authors combine hypothermic preservation and antiplatelet strategies to stabilize whole blood up to 72 h without compromising CTC yield and RNA integrity.

    • Keith H. K. Wong
    • , Shannon N. Tessier
    • , David T. Miyamoto
    • , Kathleen L. Miller
    • , Lauren D. Bookstaver
    • , Thomas R. Carey
    • , Cleo J. Stannard
    • , Vishal Thapar
    • , Eric C. Tai
    • , Kevin D. Vo
    • , Erin S. Emmons
    • , Haley M. Pleskow
    • , Rebecca D. Sandlin
    • , Lecia V. Sequist
    • , David T. Ting
    • , Daniel A. Haber
    • , Shyamala Maheswaran
    • , Shannon L. Stott
    •  & Mehmet Toner
  • Research | | open

    Glucocorticoid reduces inflammation by both inducing anti-inflammatory genes and suppressing pro-inflammatory genes, but how these two functions are dictated is unclear. Here the authors show that phosphorylated glucocorticoid receptor-interacting protein 1 (GRIP1) serves as a coactivator for this response in macrophage.

    • David A. Rollins
    • , Joubert B. Kharlyngdoh
    • , Maddalena Coppo
    • , Bowranigan Tharmalingam
    • , Sanda Mimouna
    • , Ziyi Guo
    • , Maria A. Sacta
    • , Miles A. Pufall
    • , Robert P. Fisher
    • , Xiaoyu Hu
    • , Yurii Chinenov
    •  & Inez Rogatsky
  • Reviews |

    Surgery remains the mainstay of treatment for patients with gliomas, independent of tumour grade, and maximal resection of the tumour is essential for long-term disease control. Herein, the authors discuss the current evidence on associations between the extent of glioma resection and clinical outcomes. They also describe the state-of-the-art surgical oncology approaches aimed at maximizing the extent of tumour resection while minimizing patient morbidity.

    • Nader Sanai
    •  & Mitchel S. Berger

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