GTP-binding protein regulators

Definition

GTP-binding protein regulators are proteins that regulate the function of small G proteins (heterotrimeric guanine nucelotide-binding peripheral membrane proteins involved in signal transduction). These include GTPase-activating proteins (GAPs) that accelerate GTP hydrolysis, guanine nucleotide dissociation inhibitors (GDIs) that prevent GDP dissociation, and guanine nucleotide exchange factors (GEFs) that facilitate exchange of GDP for GTP.

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