Granulocytes

Granulocytes are cells of the innate immune system that are characterized by granules in their cytoplasm. The three main types of granulocytes are neutrophils, eosinophils and basophils.

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Latest Research and Reviews

  • Research | | open

    How Japanese encephalitis virus (JEV) penetrates the blood-brain barrier (BBB) remains unclear. Here, using a genetic mouse model and a virulent JEV strain, the authors show that perivascular mast cells (MC) mediate JEV neuroinvasion and identify the MC-protease chymase as a potential therapeutic target.

    • Justin T. Hsieh
    • , Abhay P. S. Rathore
    • , Gayathri Soundarajan
    •  & Ashley L. St. John
  • Research |

    Bone marrow-derived cells can rapidly enter the systemic circulation, but how this is achieved is unclear. Grüneboom et al. identify tiny capillaries, termed trans-cortical vessels (TCVs), that connect the bone marrow cavity to the systemic vasculature, and show that the majority of blood in long bones passes through TCVs.

    • Anika Grüneboom
    • , Ibrahim Hawwari
    • , Daniela Weidner
    • , Stephan Culemann
    • , Sylvia Müller
    • , Sophie Henneberg
    • , Alexandra Brenzel
    • , Simon Merz
    • , Lea Bornemann
    • , Kristina Zec
    • , Manuela Wuelling
    • , Lasse Kling
    • , Mike Hasenberg
    • , Sylvia Voortmann
    • , Stefanie Lang
    • , Wolfgang Baum
    • , Alexandra Ohs
    • , Oliver Kraff
    • , Harald H. Quick
    • , Marcus Jäger
    • , Stefan Landgraeber
    • , Marcel Dudda
    • , Renzo Danuser
    • , Jens V. Stein
    • , Manfred Rohde
    • , Kolja Gelse
    • , Annette I. Garbe
    • , Alexandra Adamczyk
    • , Astrid M. Westendorf
    • , Daniel Hoffmann
    • , Silke Christiansen
    • , Daniel Robert Engel
    • , Andrea Vortkamp
    • , Gerhard Krönke
    • , Martin Herrmann
    • , Thomas Kamradt
    • , Georg Schett
    • , Anja Hasenberg
    •  & Matthias Gunzer
    Nature Metabolism 1, 236-250
  • Research | | open

    • Kelly L. Singel
    • , Kassondra S. Grzankowski
    • , A. N. M. Nazmul H. Khan
    • , Melissa J. Grimm
    • , Anthony C. D’Auria
    • , Kayla Morrell
    • , Kevin H. Eng
    • , Bonnie Hylander
    • , Paul C. Mayor
    • , Tiffany R. Emmons
    • , Nikolett Lénárt
    • , Rebeka Fekete
    • , Zsuzsanna Környei
    • , Uma Muthukrishnan
    • , Jonathan D. Gilthorpe
    • , Constantin F. Urban
    • , Kiyoshi Itagaki
    • , Carl J. Hauser
    • , Cynthia Leifer
    • , Kirsten B. Moysich
    • , Kunle Odunsi
    • , Ádám Dénes
    •  & Brahm H. Segal
  • Research | | open

    Neutrophils normally fulfil their metabolic demands by glycolysis and have limited mitochondrial activity. Here the authors show that tumours promote neutrophils adapted to oxidative mitochondria metabolism that function in the glucose-restrained tumour microenvironment to promote tumour growth by maintaining local immune suppression.

    • Christopher M. Rice
    • , Luke C. Davies
    • , Jeff J. Subleski
    • , Nunziata Maio
    • , Marieli Gonzalez-Cotto
    • , Caroline Andrews
    • , Nimit L. Patel
    • , Erika M. Palmieri
    • , Jonathan M. Weiss
    • , Jung-Min Lee
    • , Christina M. Annunziata
    • , Tracey A. Rouault
    • , Scott K. Durum
    •  & Daniel W. McVicar
  • Research | | open

    Neutrophil extracellular traps (NETs) are known to promote metastasis in mouse models. Here the authors show plasma redox imbalance caused by albumin oxidation to induce inflammation-independent NETosis and lung metastasis, and albumin oxidation and reduced plasma free thiol to be associated with lung metastasis in a cohort of head and neck cancer patients.

    • Minoru Inoue
    • , Ryota Nakashima
    • , Masahiro Enomoto
    • , Yuhki Koike
    • , Xiao Zhao
    • , Kenneth Yip
    • , Shao Hui Huang
    • , John N. Waldron
    • , Mitsuhiko Ikura
    • , Fei-Fei Liu
    •  & Scott V. Bratman

News and Comment

  • Research Highlights |

    This study describes a mechanism of tumour immune evasion through post-translational chemokine modification by dipeptidyl peptidase 4, which inhibits eosinophil-mediated antitumour responses.

    • Kirsty Minton
  • News and Views |

    Combined immunotherapy using checkpoint blockade (anti-CTLA4 and anti-PD-1) and the DPP4 inhibitor sitagliptin reveals the existence of a T cell– and eosinophil-targeted immunotherapy approach for solid tumors.

    • Ariel Munitz
    •  & Simon Patrick Hogan
    Nature Immunology 20, 250-252
  • News and Views |

    Gasdermin D is a pore-forming protein that can cause pyroptosis, a form of inflammatory cell death. New research indicates that the pores generated by gasdermin D can also promote the formation of neutrophil extracellular traps, potentially opening new therapeutic avenues for the treatment of inflammatory diseases.

    • Lotte Spel
    •  & Fabio Martinon
  • Research Highlights |

    Albrengues et al. have characterized a mechanism by which sustained lung inflammation can cause a switch from cancer dormancy to metastasis through the induction of neutrophil extracellular traps.

    • Anna Dart
    Nature Reviews Cancer 18, 722-723